On Sunday, Italy's champions-elect were denied victory by a late Salernitana goal that silenced a packed Stadio Maradona, but even if Lazio win on Wednesday, they will need just one more point to guarantee finishing in first place.
Match preview
Despite stumbling at the final hurdle, when their regional rivals from Salerno stunned Naples by virtue of Boulaye Dia's equaliser, it is surely just a matter of time before Napoli confirm their first Scudetto since 1990.
A third national title awaits, such is their commanding lead at the top of the table, which stands at some 18 points after a deflating 1-1 draw against Salernitana followed Lazio's loss at Inter.
In addition to tumbling out of Europe at the hands of Milan, Luciano Spalletti's side had shown signs of either nerves or fatigue in recent Serie A fixtures - perhaps both - but a last-gasp defeat of Juventus took them within touching distance of the prize which has remained elusive for three decades.
Though star forwards Victor Osimhen and Khvicha Kvaratskhelia have both seen their form dip, Napoli could still get over the line this week and be crowned champions: only two other teams this century have done so with five games left to play - Juventus four years ago and Inter in 2006-07.
Often derided for his shortage of trophies on Italian soil - though he twice led Zenit St Petersburg to the Russian title - 64-year-old Spalletti is set to become the oldest coach ever to win Serie A, and he will expect his team to get the job done on Thursday if Lazio do not slip up at home to Sassuolo 24 hours earlier and make the result in Udine inconsequential.
Before arriving at the Dacia Arena, Napoli have won each of their last eight away matches in the top flight - keeping a clean sheet in seven - and they have also won 12 of their last 13 league meetings with Udinese.
Further demonstrating the disparity between the two clubs, Udinese have conceded at least twice in each of their last six encounters, and their last home win over Napoli came back in April 2016 - since then, they have lost five and drawn one.
More recently, the Friulani - who were beaten 3-2 in November's reverse fixture - lost their top-half place by suffering another away defeat, as they returned from Lecce empty-handed in their final fixture of April.
Fresh from a 3-0 win over Cremonese, Andrea Sottil's side were undone shortly after the hour mark, when Tottenham-bound Destiny Udogie conceded a penalty and Marco Silvestri was then sent the wrong way from the spot.
As a result, their last five losses have all come on the road; by contrast, they have not lost at home in Serie A since January. In fact, the Bianconeri have already beaten both Milan clubs and Roma at the Dacia Arena this season, so hosting supreme leaders Napoli may not cause much concern.
Having recovered from an awful run of one win in 17 league matches to stabilise themselves in the standings, Udinese could feasibly finish as high as eighth if results go their way between now and June, so they will not roll out the red carpet on Thursday.
Udinese Serie A form:
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Napoli Serie A form:
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Napoli form (all competitions):
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Team News
Though Giovanni Simeone and Matteo Politano have returned to fitness and could feature in Udine, Mario Rui is still ruled out by an injury sustained in Napoli's Champions League exit to Milan. Mathias Olivera - who seemed to have scored the Partenopei's Scudetto-securing goal on Sunday - continues to deputise at left-back.
Indeed, the same XI that were held by Salernitana could take the field once again, with Hirving Lozano starting alongside the visitors' most feared forwards - though neither are enjoying their best form.
Despite making waves during his debut season in Serie A, since the start of April, Khvicha Kvaratskhelia has played more minutes than any other outfield Napoli player without scoring or providing an assist.
Victor Osimhen, meanwhile, has failed to score in his last three league appearances - the in-demand striker has yet to go four in a row without finding the net this term - but he does boast a record of four goals in as many games against Udinese.
The hosts were missing regular front pair Isaac Success (thigh) and Beto (back) due to injury as they came away from Via del Mare without scoring a goal, but both could return in midweek.
Therefore, Ilija Nestorovski will most likely make way and captain Roberto Pereyra should support 10-goal top scorer Beto in a 3-5-1-1 formation.
Gerard Deulofeu and Enzo Ebosse are out for the rest of the season, but Andrea Sottil otherwise has a full squad to choose from.
Udinese possible starting lineup:
Silvestri; Becao, Bijol, Perez; Ehizibue, Samardzic, Walace, Lovric, Udogie; Pereyra; Beto
Napoli possible starting lineup:
Meret; Di Lorenzo, Kim, Rrahmani, Olivera; Anguissa, Lobotka, Zielinski; Lozano, Osimhen, Kvaratskhelia