The hosts currently occupy sixth spot in the WSL table, while the visitors are three points further back in seventh position.
Match preview
Tottenham will head into the weekend in high spirits after they beat Man City on penalties to book their place in the FA Cup semi-finals.
Robert Vilahamn's side looked to be heading out of the competition when Mary Fowler opened the scoring in the sixth minute to give Man City the lead for the majority of the game.
However, Beth England managed to pounce on a defensive mix-up to roll home a 96th-minute equaliser, sending the tie to extra-time and penalties, with Spurs holding their nerve to convert for of their spot-kicks to Man City's three.
Spurs will hope to draw confidence from their cup success, as they turn their attention to Sunday's league fixture, where they will attempt to end a four-game winless league run.
Although they have won just one of their last six home league games, Spurs have managed to emerge victories in their previous two WSL home meetings with Leicester.
Leicester's assistant manager Jennifer Foster and first-team coach Stephen Kirby are preparing to take charge of the first team for a second straight game after manager Willie Kirk was recently suspended pending an investigation into an alleged relationship with a player.
Foster and Kirby oversaw Leicester's 2-0 success in last Saturday's FA Cup quarter-final clash with Liverpool at Prenton Park.
Finland international Jutta Rantala netted a brace to help Leicester set up a semi-final meeting against Tottenham Hotspur next month.
Before the two sides face off in the cup, Leicester will try to get the better of Spurs in Sunday's fixture as they look to secure their third away win of the WSL season.
The Foxes are also hoping to claim their first league victory over Spurs in the WSL era, having failed to win any of their previous five head-to-head matches in the top flight.
Tottenham Hotspur Ladies Women's Super League form:
W
W
L
D
L
L
Tottenham Hotspur Ladies form (all competitions):
Leicester Women Women's Super League form:
D
L
W
L
W
L
Leicester Women form (all competitions):
Team News
Tottenham will hope to have Molly Bartrip back available after the defender missed the successful cup outing against Man City due to illness.
Kit Graham dropped down to the bench for the recent FA Cup tie, but the 28-year-old could be recalled to the side for Sunday's league fixture.
England may also be presented with a starting opportunity after coming off the bench to score the all-important equaliser against Man City.
As for the visitors, Foster has confirmed that Shannon O'Brien is not ready to return to action after missing the last two matches through injury.
Leicester are also unable to call upon the series of Tottenham loanee Asmita Ale, who is ineligible to face her parent club.
Missy Goodwin and Lena Petermann could be fit for the away trip, while Canada international Deanne Rose is likely to be involved following her return from the Gold Cup.
Tottenham Hotspur Ladies possible starting lineup:
Spencer; Neville, James-Turner, Bartrip, Nilden; Graha, Summanen, Clinton; Bizet, Naz, England
Leicester Women possible starting lineup:
Kop; Bott, Howard, Thibaud, Cayman; Rantala, Tierney, Takarada, Pelgander, Nevin; Whelan