The hosts, meanwhile, will attempt to claim consecutive victories after edging out Argentinos Juniors in their most recent outing.
Match preview
After rounding off the month of June with a 2-0 defeat to Sao Paulo in the Copa Sudamericana, Tigre began July with another disappointing result.
Tigre were edged out by a narrow 1-0 scoreline in Saturday's away meeting with Defensa y Justicia, representing their fourth loss in the last five league games.
Having mustered just one win in their previous nine top-flight matches, Tigre are currently sitting in 19th place in the league table.
Although Tigre may be enduring a poor spell of form, they have proven to be a tough team to beat on home turf in recent times, losing just one of their last seven home league fixtures.
After scoring the first goal in each of their six league wins this season, El Matador may need to strike first if they are to claim all three points on Wednesday.
Tigre's opponents will head into the midweek encounter in a buoyant mood after they ended a run of three consecutive league defeats with a narrow victory over Argentinos Juniors on Saturday.
A second-half strike from Milton Gimenez proved to be decisive, as Banfield kept Argentinos Juniors at bay to clinch a 1-0 victory.
Despite picking up a win at the weekend, Banfield are currently languishing in 26th place with 21 points to show for their 22 games.
Having collected just five points on the road this season, the visitors will need to improve on their travels if they are to move up the table.
Although they have won just one of their 10 away league games this term, Banfield can take confidence from the fact that they are unbeaten in their previous five away meetings with Tigres (W3, D2).
Tigre Argentine Primera Division form:
D
L
L
L
W
L
Tigre form (all competitions):
L
W
L
W
L
L
Banfield Argentine Primera Division form:
L
W
L
L
L
W
Team News
Tigre are expected to be without the services of Sebastian Prieto, Alexis Castro and Lucas Menossi, who are all nursing injury issues.
After dropping down to the bench at the weekend, Agustin Cardozo could be recalled to the starting lineup for Wednesday's contest.
Mateo Retegui will continue to lead the line for the hosts, and he will be looking to add to the 10 league goals he has scored this season.
As for the visitors, they are unable to call upon the injured trio of Alexis Maldonado, Andres Chavez and Horacio Tijanovich.
Aaron Quiros is set to make his third consecutive start for Banfield, and he is expected to be joined in the centre of defence by Alejandro Maciel.
After registering four goals in his last five games, Gimenez will be hoping to continue his fine form when he features up front on Wednesday.
Tigre possible starting lineup:
Marinelli; Garay, Cabrera, Luciatti, Montoya; Cardozo, Zabala; Armoa, Molinas, Colidio; Retegui
Banfield possible starting lineup:
Cambeses; Coronel, Maciel, Quiros, Insua; Remedi, Cabrera; Sanchez, Aleman, Bisanz; Gimenez