The hosts come into the tie following a defeat against Birmingham City, while the visitors travel to Staffordshire in good spirits owing to a victory over Blackpool last weekend.
Match preview
Stoke have made an underwhelming start to the 2022-23 campaign, currently occupying 19th place in the Championship table under the stewardship of Alex Neil.
Their home form has been poor to say the least, as Stoke have the second-worst record on their own patch in the entire league, picking up just eight points from a possible 27.
The Potters have also only scored 20 times this season from their 19 fixtures, demonstrating a lack of prowess in attack, which has left them facing a fight to avoid dropping into the relegation places.
Last time out, Stoke were on the end of a 2-1 loss to Birmingham at the Bet365 Stadium, as goals from Scott Hogan and Harlee Dean were enough to condemn the home side to defeat despite a Lewis Baker consolation.
There will need to be a big improvement this midweek against Luton as Stoke aim to elevate themselves further away from the relegation zone with a win.
Luton travel to Staffordshire unbeaten in three matches and will be keen to move closer to the playoff positions with a win on Tuesday.
Nathan Jones has won many plaudits for his side's displays at the back, with the Hatters conceding just 19 goals so far this season which is one of the best defensive records in the division.
Furthermore, Luton have the third-most impressive away record in the Championship, claiming 17 points from a possible 27 which has made up the bulk of their points in the league this season.
Luton sit eighth in the Championship and could move up to as high as fourth with a win against Stoke, depending on other results.
Jones will hope his side can continue their stellar form on the road and take another step forward in their hunt for promotion.
Stoke City Championship form:
W
L
L
L
W
L
Luton Town Championship form:
W
W
L
D
D
W
Team News
Stoke City will be without Josh Laurent and Gavin Kilkenny for the visit of Luton as the pair are ruled out due to respective injuries.
Lewis Baker, Liam Delap and Connor Taylor all risk suspension should they pick up a yellow card during the match.
On the other hand, Luton will not be able to call upon James Shea, Sonny Bradley, Reece Burke and Henri Lansbury for the trip to the Bet365 Stadium as all are nursing various knocks.
Forward Carlton Morris risks suspension if he picks up a booking during the midweek clash for the visitors.
Stoke City possible starting lineup:
Bursik; Wilmot, Flint, Fox; Fosu, Clucas, Baker, Smallbone, Brown; Delap, Campbell
Luton Town possible starting lineup:
Horvath; Bree, Lockyer, Potts; Clark, Berry, Ruddock, Bell; Campbell, Adebayo; Morris
We say: Stoke City 1-1 Luton Town
In a match with permutations at both ends of the table, we expect a close encounter that will yield its fair share of chances for either side.