The hosts, meanwhile, will hope to put further distance between themselves and the relegation zone.
Match preview
After seeing their relegation rivals Sampdoria surprisingly claim all three points away to Sassuolo earlier in the day on Wednesday's bumper-filled Serie A action, Spezia boss Luca Gotti may have feared the worst ahead of his side's home match against Atalanta.
The Black and Blues have been one of the most formidable sides on the road throughout Gian Piero Gasperini's reign and this season has been no different with them winning five and losing just one of their seven away trips, so to claim a 2-2 draw against them was no mean feat for Spezia.
However, having led 2-0 until Rasmus Hojlund pulled one back with 13 minutes of normal time remaining, Mario Pasalic's injury-time equaliser was a cruel blow for Gotti's side, who saw their gap ahead of the bottom three cut to five points as a result.
As such, they will be keen to return to winning ways against Lecce on Sunday, but that will be no easy task given their opponents' brilliant form in recent matches.
Indeed, having only been promoted from Serie B as champions last season, even the most optimistic of Lecce fans would have struggled to envisage their side's healthy position in the table at this stage of the season.
The Yellow and Reds pulled off a stunning comeback to defeat Lazio 2-1 at Stadio Via del mare on Wednesday, with second half strikes from Gabriel Strefezza and Lorenzo Colombo overturning Ciro Immobile's early opener.
That made it three wins in a row for the newly promoted side having beaten Atalanta and Sampdoria prior to the World Cup, and it has taken them nine points clear of the relegation zone after 16 matches.
However, head coach Marco Baroni will be acutely aware that there is a long way of the season to go, especially having been relegated with Frosinone in 2019. With their next match being against an in-form AC Milan side, he will be determined to see his side maintain their winning momentum this weekend.
Spezia Serie A form:
L
L
L
D
W
D
Lecce Serie A form:
L
L
D
W
W
W
Team News
Spezia could be without both of their senior goalkeepers after Jeroen Zoet was withdrawn due to injury against Atalanta, meaning 20-year-old Petar Zovko may start between the posts for the hosts.
Daniele Verde also remains an injury doubt, while Albin Ekdal could be drafted in from the start in order to provide more experience in midfield.
Lecce, meanwhile, will travel without Morten Hjulmand after the holding midfielder received his fifth caution of the season during the win against Lazio on Wednesday.
Youssef Maleh, who joined on loan from Fiorentina last week, could be handed his first start for the club after making his debut from the bench last time out.
Spezia possible starting lineup:
Zovko; Amian, Kiwior, Nikolaou; Holm, Ekdal, Ampadu, Bastoni, Reca; Nzola, Gyasi
Lecce possible starting lineup:
Falcone; Gendrey, Baschirotto, Umtiti, Gallo; Blin, Maleh, Gonzalez; Strefezza, Colombo, Banda
We say: Spezia 1-2 Lecce
Spezia's collapse against Atalanta would have concerned their manager Gotti, who is likely to be forced into starting an inexperienced youngster in goal due to injuries.
As such, we would not be surprised if Lecce extend their winning run to four matches on Sunday.