La Roja will enter the contest off the back of a goalless draw with Portugal on Friday, while Lithuania suffered a 3-1 loss to Latvia in the Baltic Cup on the same evening.
Match preview
Spain, as mentioned, played out a 0-0 draw with Portugal on Friday night, but La Roja will be keen to enter Euro 2020 off the back of a win and ideally a positive performance.
Luis Enrique's side have been drawn into Group E this summer alongside Poland, Slovakia and Sweden - three extremely capable teams - but it would be a huge surprise if they did not progress to the knockout stages.
Spain, who are unbeaten in their last seven matches in all competitions, have won two of the last three European Championships, but they failed to make an impression at Euro 2016, being eliminated in the round of 16 by Italy.
Enrique is certainly taking the national team in a new direction, with a number of younger players being given chances to make their mark at this level, and it was a very bold decision from the head coach to leave Sergio Ramos out of his squad for the European Championships.
Time will tell whether this Spain side is capable of making a serious impression at Euro 2020, but the amount of talent in their squad means that it is difficult to write them off.
Lithuania, meanwhile, have suffered back-to-back defeats in the Baltic Cup this month, losing 1-0 to Estonia on June 1 before suffering a 3-1 reverse to Latvia on Friday.
Valdas Urbonas's side have now lost each of their last five matches in all competitions, including defeats to Switzerland and Italy in their opening two 2022 World Cup qualification fixtures.
Lithuania have never qualified for the finals of a World Cup or European Championship, meaning that it was not a surprise to see them fail to book their spot at Euro 2020.
The National Team actually finished bottom of Group B during qualification for this summer's tournament, picking up just one point from eight matches, which is an indication of their struggles.
Lithuania's next competitive match is a World Cup qualifier against Northern Ireland at the start of September, but they will be desperate to pick up a positive result against Spain on Tuesday evening.
Spain International Friendlies form:
Spain form (all competitions):
Lithuania International Friendlies form:
Lithuania form (all competitions):
Team News
Spain's XI is expected to have a similar look to the one that took to the field against Portugal, with Enrique giving an indication of who will start their Euro 2020 opener.
Aymeric Laporte should win his second cap in the middle of the defence, while Sergio Busquets could again be joined by Thiago Alcantara and Fabian Ruiz as part of a midfield three.
Ferran Torres and Alvaro Morata should both retain their spots in attack, but it seems likely that Gerard Moreno, who enjoyed an excellent 2020-21 campaign for Villarreal, will come in for a start.
Pedri, Rodri and Koke should all receive minutes off the bench, while Jordi Alba - an unused substitute against Portugal - could replace Jose Gaya at left-back for the home side.
As for Lithuania, Arvydas Novikovas is the leading goalscorer in the squad with 12, and the 30-year-old should again feature in an attacking position for the visitors.
Fedor Cernych, who has struck nine times in 63 caps, is also likely to be given the nod in the final third of the field, with Karolis Laukzemis potentially operating in a wider area.
Captain Saulius Mikoliunas should earn his 95th international cap on Tuesday evening, while there could also be a Lithuania debut for Lecce's Edgaras Dubickas.
Spain possible starting lineup:
Simon; M Llorente, Laporte, P Torres, Alba; Thiago, Busquets, Ruiz; F Torres, Morata, G Moreno
Lithuania possible starting lineup:
Svedkauskas; Mikoliunas, Beneta, Girdvainis, Vaitkunas; Dapkus, Simkus, Eliosius; Novikovas, Cernych, Laukzemis
We say: Spain 2-0 Lithuania
The result is not particularly important on Tuesday night, but Spain will be keen to enter Euro 2020 off the back of a win and a strong performance. Lithuania could make it uncomfortable for La Roja, but we are finding it very difficult to predict anything other than a routine victory for Enrique's side.