The Rossoneri lead 4-2 from an exhilarating first leg, which leaves the tie swayed heavily in their favour, but not yet over by any means.
Match preview
A spirited performance from 10-man Slavia saw them keep the tie alive despite being heavily up against it, playing with a man light for over an hour.
El Hadji Malick Diouf's early red card had the Czechs on the backfoot early on, and after Olivier Giroud's opener, it only looked like going in one direction.
However, David Doudera's scorching volley was too hot to handle for Mike Maignan and pulled the visitors level, silencing San Siro.
Milan would go into the break with a two-goal lead though, thanks to late first-half strikes from midfield duo Tijjani Reijnders and Ruben Loftus-Cheek.
Another eye-catching strike pulled Jindrich Trpisovsky's back into it though, as Ivan Schranz lashed one home midway through the second half to make it 3-2, but Christian Pulisic made the most of excellent work from Rafael Leao to restore that two-goal advantage.
While being the big outsiders having to claw back the deficit, Slavia can take positives into the second leg as they chase a fourth European quarter-final in six seasons.
Historical results at home to Italian opposition make for encouraging reading to Slavia too, as they have won four and drawn two of their eight meetings with Serie A side on home turf.
A two-goal win is needed to at least force extra time though, but they did manage that when they welcomed Italian opposition to the Fortuna Arena in the group stages, as Roma were beaten 2-0 here by the Cervenobili in November.
The weekend's 4-0 thumping of Teplice may give them additional confidence heading into this one, as paired with Sparta Prague's heavy defeat to Viktoria Plzen, Slavia are right back in the title race domestically.
Knockout football in the Europa League has not been their forte of late though, especially at home, as they have failed to win any of their previous four knockouts games here in this competition, scoring just one goal in the process.
Milan have only won on two of their six trips to Czechia though, but one of those did come against Slavia's cross-town rivals Sparta in 2020-21.
While the lead looks comfortable, much is made about the fact Milan have a history of throwing away big leads in European ties, notably in the 2005 Champions League final, and the 2003-04 quarter-final against Deportivo La Coruna, where they lost after being 4-1 up from the home leg.
Even in this competition, the Rossoneri have blown a healthy first-leg lead, losing to Bordeaux back in 1996 despite leading 2-0 from the first leg.
The current crop did their best to dispel this myth by holding onto their 3-0 lead over Rennes in the previous round, progressing comfortably despite losing the second leg in France.
With just one win in their last seven European away games though, Stefano Pioli must ensure his side keep the game in their control in the early stages.
Last season's Champions League semi-finalists are still seeking a first-ever title in this competition, with their best showing being semi-final defeats in 1972 and 2002.
In their two most recent knockout stage appearances in the Europa League, English opposition got the better of them at this stage, with Arsenal (2017-18) and Manchester United (2020-21) knocking the Rossoneri out.
Slavia Prague Europa League form:
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L
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Slavia Prague form (all competitions):
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AC Milan Europa League form:
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AC Milan form (all competitions):
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Team News
Diouf will be suspended for this second leg after his red card at San Siro last midweek on his debut in European competition.
The Senegalese teenager will be joined by Petr Sevcik and Christos Zafeiris on the sidelines here, with the latter still recovering from an ankle injury.
David Pech and Sheriff Sinyan remain out long-term for the hosts, as they could remain largely unchanged, apart from Jan Boril replacing Diouf at left-back
Bookings for Alessandro Florenzi in his last two Milan appearances triggered two separate suspensions for the veteran, one domestically and one on the continent, and after serving one against Empoli at the weekend, he will serve another here.
Tommaso Pobega is the only known injury absentee for the Italians, as Pioli may go strong knowing he cannot afford to rotate too heavily, with the job not yet done.
Giroud opened the scoring last Thursday, netting his 15th Europa League goal, and his first since the 2019 final for Chelsea against his former club Arsenal, and the 37-year-old will compete with Luka Jovic for a starting spot here, with the Serbian likely to drop out after starting in the league on Sunday.
Slavia Prague possible starting lineup:
Stanek; Vlcek, Holes, Zima, Boril; Doudera, Masopust, Dorley, Provod, Zmrzly; Chytil
AC Milan possible starting lineup:
Maignan; Calabria, Kjaer, Gabbia, Hernandez; Bennacer, Reijnders, Loftus-Cheek; Pulisic, Giroud, Rafael Leao
We say: Slavia Prague 2-2 AC Milan
Milan have been involved in plenty of thrilling encounters recently with many goals, including in the second leg of their playoff tie with Rennes, but they should still have enough to comfortably navigate this encounter even if Slavia get on the scoresheet.