Both sides head into the term under new management, with Xisco Munoz and Russell Martin set to take charge of their first competitive games as Owls and Saints bosses respectively in the curtain-raiser.
Match preview
Sheffield Wednesday will make their return to the Championship on Friday after successfully putting an end to a two-year stay in League One in dramatic fashion last term, having eventually finished third in England's third tier, just missing out on automatic promotion despite earning an eye-catching tally of 96 points from their 46 outings under Darren Moore.
They then met Peterborough United in the playoffs, and after a 4-0 defeat away from home, the Owls pulled off a historic comeback at Hillsborough as Michael Smith, Lee Gregory, Reece James and Liam Palmer scored in normal time to level the aggregate score, before Callum Paterson again equalised in extra time, forcing a penalty shootout which the Owls prevailed in to book a trip to Wembley against local rivals Barnsley.
That contest remained goalless throughout the 90 minutes and looked set to go to another shootout in the capital, but Josh Windass would eventually head in the decisive goal in the 123rd minute to seal his side's climb back to England's second tier, although it has not been smooth sailing for the Owls since that triumph.
Moore would depart by mutual consent in mid-June, and Xisco Munoz was then tasked with leading the South Yorkshire outfit into the new term, starting pre-season with a draw against York City and a victory over Chesterfield, before suffering defeats to Burnley, Eldense, Doncaster Rovers alongside a draw with Real Murcia and finishing their preparations with a narrow 2-1 loss at home to Premier League-bound Luton Town last Saturday, as Michael Smith's opener from the penalty spot was followed by goals from Pelly-Ruddock Mpanzu and Carlton Morris for the visitors.
With their pre-season campaign now complete, the Owls will be keen to mark their return to the Championship with a positive result in front of their home crowd on Friday.
They face a tough test, though, as the visitors also arrive under new management hoping to make a mark in the second tier, after the relegation from the Premier League last season.
In their 11th consecutive campaign in England's top flight, the Saints were unable to avoid the drop, with long-serving manager Ralph Hasenhuttl departing in November, before his replacement Nathan Jones lasted for just eight league outings, winning just three points along the way between mid-November and mid-February.
Ruben Selles would then step up to lead the Saints for the remainder of the season, and they were condemned to relegation and finished at the foot of the table with just 25 points on the board, as they went winless for the last 12 outings while only managing four draws, including a dramatic final-day meeting with Liverpool which ended 4-4 at St Mary's.
Over the summer and ahead of their bid to return to the top flight, Southampton turned to Russell Martin over the summer, and his tenure began in pre-season with a defeat to Benfica, a draw with Goztepe and a victory over Reading, before finishing their preparations at home to Bournemouth and AZ Alkmaar and suffering 3-2 and 1-0 defeats respectively.
Now with their focus fully on Friday's curtain-raiser, Southampton will look to kick off their season with a three-point haul on their travels on Friday in their bid to establish themselves in the leading pack from the outset.
Sheffield Wednesday form (all competitions):
Southampton form (all competitions):
Team News
Sheffield Wednesday have several summer signings fighting for competitive debuts for the club in Friday's curtain-raiser, with defenders Di'Shon Bernard, Bambo Diaby and Pol Valentin having arrived alongside winger Juan Delgado and forward Ashley Fletcher.
With Munoz expected to line the Owls up in a 4-3-3 shape, Bernard and Diaby will compete with Michael Ihiekwe and Dominic Iorfa to start at the heart of a back four, while captain Barry Bannan should continue to join George Byers and Will Vaulks in midfield., although Callum Paterson will also compete for a spot after moving back from his usual attacking position late last season.
Competition for spots in the front line is rife, with Josh Windass bound to feature after contributing 12 goals and seven assists in their promotion-winning campaign last time around, and Michael Smith, Lee Gregory and Fletcher all hoping to lead the line, while Delgado, Marvin Johnson and Mallik Wilks are also vying to feature on the flanks.
While Southampton have only lost defenders Mohammed Salisu and Dujje Caleta-Car, midfielder Ibrahima Diallo and wingers Mohamed Elyounoussi, Theo Walcott and Mislav Orsic so far this summer, doubts do remain over several other key players, with Armel Bella-Kotchap, Lyanco and Romeo Lavia also looking set to depart imminently.
Without Caleta-Car and Salisu, and with Lyanco and Bella-Kotchap not expected to feature, Jack Stephens should start at the heart of a back four following a loan spell with AFC Bournemouth, likely joining Shea Charles, who ended pre-season at the back after the traditional midfielder arrived from Manchester City in the summer.
Talismanic captain James Ward-Prowse, on the other hand, does look set to stay with the Saints and is bound to play a key role in midfield, potentially alongside William Smallbone with Lavia not expected to feature, while Adam Armstrong and Che Adams will both hope to lead the line with support from the likes of Samuel Edozie, Charly Alcaraz and Nathan Tella, who returned to the club following a successful loan spell with Championship winners Burnley last season, in which he netted 17 goals and provided five assists in 39 second-tier appearances.
Sheffield Wednesday possible starting lineup:
Dawson; Palmer, Bernard, Iorfa, James; Vaulks, Byers, Bannan; Windass, Smith, Delgado
Southampton possible starting lineup:
Bazunu; Livramento, Stephens, Charles, Manning; Ward-Prowse, Smallbone; Tella, Alcaraz, Edozie; Adams