The hosts are seeking to record a fourth victory in five matches while the away side set out to pick up a seventh win on the bounce.
Match preview
Wuhan Three Towns recorded their joint-biggest victory of the season as they handed out a 5-0 thrashing to Wuhan FC on Friday morning.
Ademilson was the star of the show, scoring two goals and setting up one for Nicolae Stanciu while Davidson and Kuo Yang also got on the scoresheet.
Pedro Morilla's men remain top of the league table, one point ahead of nearest challengers Shandong Taishan albeit having played a game less.
Next up is the task of facing off against an opposing side who suffered a 2-1 defeat in the only meeting between the teams on June 19.
Having dropped just two points in their four matches on the road this term, Tuesday's visitors will certainly take some stopping to prevent them from keeping the juggernaut rolling on.
Shanghai Port got the better of relegation-threatened Guangzhou FC in a narrow 1-0 triumph at the Jinzhou Stadium in Dalian on Friday.
Ivan Leko's men were in the ascendancy for the majority of the contest but had to wait until the 83rd minute to break the deadlock thanks to Oscar's penalty.
The Red Eagles have picked up 10 of the last 12 points available which has seen them move up to sixth place in the standings and just four points off a continental spot.
With just one defeat in five home matches since the turn of the year, Tuesday's hosts will be confident of coming away from this one with a positive result.
Shanghai Port Chinese Super League form:
Wuhan Three Towns Chinese Super League form:
Team News
Nicolae Stanciu has scored in each of his last four games for Wuhan Three Towns and he is definitely one to keep an eye on here.
Kuo Yang came off the bench to put the final nail in the coffin against Wuhan FC and the 29-year-old could be rewarded with a start in this one.
Oscar grabbed his first goal of the season last time out having recently returned to action and the midfielder will be looking to make up for lost time.
Cherif Ndiaye has now gone two games in a row without scoring for the first time this term but the Senegalese still poses a significant attacking threat.
Shanghai Port possible starting lineup:
Yan; Li, Wei, He; Lu, Oscar, Chen, Feng, Li; Paulinho, Ndiaye
Wuhan Three Towns possible starting lineup:
Liu; Wallace, Yaki, Hang; Deng, Xie, Zhang, Stanciu, Zhang; Ademilson, Davidson