Both clubs kick off the weekend of top-flight football in Italy riding high off the back of victories over Champions League-chasing opposition, with Sassuolo edging Roma in a bonkers Sunday night thriller while Spezia defeated Inter last Friday.
Match preview
Roma had conceded five league goals at home all season before Sassuolo arrived at the Stadio Olimpico and emerged with four goals and three points from a breathless 4-3 thriller last weekend.
Jose Mourinho's capital outfit are not the only lofty name to fall against Sassuolo this calendar year; Alessio Dionisi's side kickstarted their recent glut of good form by romping to a 5-2 victory at Milan's San Siro in January.
Since that statement triumph, Sassuolo have collected 16 points from their last seven league games - only Napoli can better that tally but not even the runaway league leaders can match Sassuolo's haul of 16 goals in the same time frame.
The Neroverdi have had to discover a prolific edge given the dreadful season Andrea Consigli is enduring between the sticks; the veteran goalkeeper is recording the lowest save percentage in the whole of Serie A, conceding two out of every five shots which fly his way.
Despite the recent uptick in form, Sassuolo remain firmly ensconced in mid-table, nine points adrift of the European spots but with a double-digit gap to the relegation zone.
Spezia, by contrast, do not have much of a cushion above the dotted line, sitting in 17th, five points above Hellas Verona in the drop zone.
Serie A endured a sparse January transfer window but Spezia were the second-biggest spenders as they tried to address their precarious positioning with a €7.7m outlay on 11 players - however, this expenditure was financed by the loss of starting centre-back Jakub Kiwior to Arsenal for €25m.
Luca Gotti was manager during the winter outlay but the club turned to Leonardo Semplici in February; the former SPAL boss has only taken charge of three matches but is yet to lose, taking five points since his appointment.
Semplici credits a team meal he organised shortly after his arrival with the strong bond forged between the coach and his new squad; the detailed knowledge of his players was evident when Semplici changed formation and personnel at half time to inspire Spezia to the club's first-ever victory against Inter last Friday.
Daniel Maldini was one of the half-time changes Semplici deployed against the Nerazzurri when switching from a 3-5-2 to a back four, with the 21-year-old coming off the bench to score 19 years after his father - the Milan icon Paolo Maldini - last found the net against Inter.
Sassuolo Serie A form:
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D
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Spezia Serie A form:
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Team News
Sassuolo's Ruan Tressoldi, who got sent off on his first appearance of the season, is suspended again after collecting his fifth yellow card of the campaign last weekend.
Injury and ill-discipline have limited the number of starts that Armand Lauriente, Andrea Pinamonti and Domenico Berardi have been able to make in attack alongside each other, but all three are set to be available again and full of confidence after each member of the trio scored against Roma.
Spezia's Ligurian-born full-back Simone Bastoni has not been able to appear for his local club since January while nursing a meniscal injury.
Fellow defender Joao Moutinho was one of the club's winter acquisitions but is yet to make a league start after picking up a foot problem while Emil Holm is set to be sidelined with a tendon issue until April.
Semplici may be tempted to deploy Maldini and his fellow substitute Albin Ekdal from the start after the pair had such a positive impact off the bench against Inter.
Sassuolo possible starting lineup:
Consigli; Toljan, Erlic, Ferrari, Rogerio; Matheus Henrique, Lopez, Frattesi; Berardi, Pinamonti, Lauriente
Spezia possible starting lineup:
Dragowski; Amian, Ampadu, Nikolaou, Reca; Agudelo, Ekdal, Maldini; Verde, Nzola, Gyasi