The Lancashire outfit will head into the game seeking to get one over the hosts after suffering defeats in both home and away fixtures when the sides squared off in the League One last season.
Match preview
Rotherham United maintained their solid start to life back in the Championship as they held on for a 1-1 draw away to Queens Park Rangers when the sides met on Saturday.
Despite being on the back foot at the Loftus Road Stadium, Chiedozie Ogbene struck against the run of play to hand the visitors a 33rd-minute lead before Christopher Willock restored parity on the stroke of half time.
The Millers, who finished second in the League One to secure promotion to last season, are one of just four sides yet to suffer defeat in the Championship this term after picking up one win and three draws from their opening four games.
Paul Warne's side now turn their sights to the EFL Cup, where goals from Oliver Rathbone and Ogbene helped them pick up a hard-earned 2-1 victory away to League One outfit Port Vale in the opening round on August 10.
Rotherham United head into Tuesday's contest unbeaten in each of their last 15 games across all competitions, claiming eight wins and seven draws since April's 2-0 loss against Burton Albion.
Morecambe, on the other hand, were denied their first win of the new League One campaign when they were held to a 1-1 draw by Oxford United on Saturday.
Following a drab first half at the Kassam Stadium, Jensen Weir broke the deadlock three minutes into the second period, but former Swansea striker Kyle Joseph netted eight minutes later to hand the Yellows a point.
Having stuttered in the final stages of the 2021-22 campaign, Karl Robinson's men have now failed to taste victory in their opening five league games, picking up three draws and losing twice in that time.
Morecambe, who saw off Stoke City on penalties in their EFL Cup opener two Tuesdays ago, will head into the midweek clash desperate to find their feet and surpass their 2021-22 cup run, where they suffered a second-round exit against Preston North End.
Rotherham United EFL Cup form:
Rotherham United form (all competitions):
Morecambe EFL Cup form:
Morecambe form (all competitions):
Team News
Rotherham United remain without the services of 21-year-old forward Joshua Kayode, who has been out of action since June through a muscle injury.
With his strike against QPR last time out, Ogbene has now scored four goals in the opening five games and the Irish forward will be one to keep an eye on.
As for Morecambe, Adams will be unable to call upon the services of Courtney Duffus, who has been out of action since February through a long-term injury.
Ashley Hunter came off with a game-ending injury seven minutes into the game against Oxford United on Saturday and the 26-year-old midfielder is expected to sit out Tuesday's encounter.
In his absence, French international Fane Ousmane will push for his fourth starting appearance of the season, teaming up with Liam Gibson and Weir at the centre of the park.
Rotherham United possible starting lineup:
Johansson; Peltier, Hall, Humphreys; Harding, Lindsay, Barlaser, Wiles, Bramall; Ogbene, Washington
Morecambe possible starting lineup:
Ripley; Taylor, Delaney, Bedeau, Rawson, Love; Weir, Gibson, Ousmane; Obika, Gnahoua
We say: Rotherham United 2-0 Morecambe
While Morecambe will be looking to pick up a morale-boosting result and march on in the cup competition, standing in their way is a rampant Rotherham United side who are unbeaten in 15 straight games. We are backing the home side to make light work of the Shrimps, who have struggled for results since the second quarter of the year, and come away with a comfortable win.