While the Friulani secured a shock 4-0 win in September's reverse fixture, they have taken just one point from two games ahead of their trip to the capital, where Jose Mourinho's men have won nine times out of 14 in the league.
Match preview
Roma's 1-0 loss to Feyenoord in the first leg of the clubs' Europa League contest left a trail of pain in its wake for the Giallorossi, as not only did captain Lorenzo Pellegrini miss a chance to put his side ahead from the penalty spot but their two star strikers were withdrawn due to injury.
Either side of Pellegrini's spot-kick striking the hosts' upright, Paulo Dybala and Tammy Abraham were forced off injured on a miserable night for Mourinho and co at De Kuip.
Beaten by the side they defeated to win last year's Europa Conference League final, Roma will have an opportunity redeem themselves and make it into the final four when they reconvene with the Rotterdam club next week, but first they return to Serie A duty on Sunday.
After Dybala's early penalty earned a 1-0 win over Torino last time out in the league, they have now won without conceding a goal on eight separate occasions in 2023 - a record equalled only by Napoli - and sit third in the table with nine rounds remaining.
Thanks to Mourinho's grim pragmatism, Roma have picked up the most points in relation to goals scored, at a rate 1.36 points per goal, and the veteran coach has helped them grind their way to within touching distance of a Champions League return.
Beating Torino ended a six-game wait for an away win, and they are now back on home soil in search of another victory against one of their favourite visitors: they have won eight of their last nine league meetings with Udinese at Stadio Olimpico.
Following up their trouncing of Roma back in the autumn - when Destiny Udogie opened the scoring and Sandi Lovric finished the job with a flourish - will prove no mean feat for a Udinese side that have failed to maintain their form of those days, when they were being touted by some optimists as potential top-six contenders.
The Fruilani have not done the double over Sunday's hosts since 1998, but have at least avoided defeat in both of the teams' last two encounters - as many times as they managed in the previous 17.
Lovric was on target again last weekend, when Beto's stoppage-time conversion from the spot rescued a point at home to Monza, after Udinese had conceded twice in the space of 10 minutes after the break.
Previously beaten in Bologna, Andrea Sottil's side have won just two of their last 11 away games in Serie A and have failed to find net on four of their last seven road trips, so a trip to the Olimpico could prove quite daunting.
Their primary ambition for the rest of the season is to secure a top-half finish for the first time in 10 years, but upcoming clashes with Cremonese and Lecce may prove more helpful in that regard.
Roma Serie A form:
L
W
L
L
W
W
Roma form (all competitions):
L
D
L
W
W
L
Udinese Serie A form:
D
D
W
W
L
D
Team News
Roma could make several changes to their team between two legs of a continental quarter-final, and Lorenzo Pellegrini may even find himself rested after being withdrawn at half time on Thursday and having failed to score from open play since September.
Ola Solbakken and Rick Karsdorp remain unavailable, but Giorginio Wijnaldum, Diego Llorente and Stefan El Shaarawy could all come into the starting XI.
In the aftermath of their trip to the Netherlands, Paulo Dybala (thigh) and Tammy Abraham (shoulder) are both set to miss out through injury. Not only is Dybala the hosts' top scorer this term but he has also been directly involved in 17 goals against Udinese in the past, so will be particularly missed.
Two forwards who have played the most Serie A games this season without finding the net could therefore face each other: Abraham's deputy Andrea Belotti (23 appearances) and Udinese's Isaac Success (28).
By contrast, the Bianconeri's Beto reached double figures for the 2022-23 campaign last week; however, his last away goal dates back to October.
Roberto Pereyra will be back from suspension to take the captain's armband, but Gerard Deulofeu may not return from a long layoff until later this month.
Roma possible starting lineup:
Patricio; Mancini, Smalling, Llorente; Zalewski, Cristante, Matic, Spinazzola; Wijnaldum, El Shaarawy; Belotti
Udinese possible starting lineup:
Silvestri; Becao, Bijol, Perez; Ehizibue, Lovric, Walace, Pereyra, Udogie; Success, Beto
We say: Roma 1-0 Udinese
While Roma have failed to win any of the last nine league games in which they have conceded at least once, keeping another clean sheet on Sunday would avert that problem.