The sides are separated by four points in the standings, with both aiming to boost their Scudetto credentials at the other's expense. While the visitors remain unbeaten, the Giallorossi have won their last three league matches following Monday's success at Sampdoria.
Match preview
Setting a relentless pace at the top of both Serie A and Champions League Group A, Napoli have won each of their last 10 games in all competitions, and only once in their history have they enjoyed a longer winning run.
Back in their mid-80s heyday, the Campanian club managed to string together 11 on the bounce, and victory in Rome this week would match the feats of 1986.
Their most recent three points did not come easy, though, as a 69th-minute Victor Osimhen goal was required to edge out Bologna in a 3-2 home win last Sunday - a result which keeps the Partenopei top of the table; leading closest rivals Atalanta by two points.
Among their 25 league goals this term, and a scarcely believable 17 from four fixtures in Europe, Napoli have recorded 15 different scorers. Level with perennial Bundesliga champions Bayern Munich, that represents the most by any team throughout the top five European Leagues.
The architect of such attacking prowess, Luciano Spalletti's quiet revolution has only gathered pace since his side crashed out of the title race late last term, and reigning champions Milan are the only side to have posted more points in Serie A this calendar year.
Now being talked of as Scudetto favourites and contenders to prevail in the Champions League, the Azzurri are set to face Liverpool and Atalanta in the coming weeks, after tackling Roma on Sunday, so can expect to be fully tested before the World Cup intervenes.
Having slipped off the pace of their southern rivals in recent times, Roma have won only one of their last eight league meetings with Napoli - including a pair of draws last season - and their last victory came back in November 2019.
This year, they trail in the Neapolitans' wake once again, but Jose Mourinho's second season at the club seems to promise greater things for the Europa Conference League winners.
After captain Lorenzo Pellegrini coolly converted an early penalty at Stadio Luigi Ferraris on Monday, ultimately securing the Giallorossi's seventh league win from 10 games to date, they sat fourth in the standings - a point above bitter foes Lazio and just one below Milan.
Roma have now won their last three Serie A matches and would win four in a row for the first time under Mourinho if they can become the first team to topple the leaders this season.
However, a long-standing weakness against other top-six candidates means they are winless in their last 12 home matches against sides in the first four places at the start of that matchday; losing each of the most recent three.
Their last such victory was over three years ago, under Claudio Ranieri, but a shift in mentality may be afoot: Roma overcame Inter at San Siro earlier this month, and as champions in the continent's newest club competition, they have had to see games out under intense pressure.
Next week, they return to Europa League action with plenty of work left to secure their spot in the knockout stages. Between now and then, though, lies a fixture to truly test the mettle of Mourinho's men.
Roma Serie A form:
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Roma form (all competitions):
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Napoli Serie A form:
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Napoli form (all competitions):
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Team News
Aiming to extend their incredible winning run at the place it first started - with September's 2-1 win at Lazio - Napoli return to Stadio Olimpico facing something of a selection dilemma up front.
With Victor Osimhen now fully back in the fold following injury, Luciano Spalletti must choose between last term's top scorer and this season's stars - Giacomo Raspadori and Giovanni Simeone.
While that may be a particularly pleasant decision to mull over, the ex-Roma coach will once more be without regular centre-back Amir Rrahmani, whose recent thigh injury could keep him out until 2023. Another former Giallorosso, Juan Jesus, should deputise.
Andre-Frank Zambo Anguissa returned to training at the end of the week, after recovering from a thigh problem of his own, but the Cameroon midfielder will make the bench at best.
Summer signing Khvicha Kvaratskhelia has been involved in 13 goals in 14 appearances for Napoli this season - more than any other Serie A player in all competitions - and has delivered one assist in each of his last four games. The Georgian winger features on the left of a front three for the visitors.
Meanwhile, Roma's most productive player, Paulo Dybala, is consigned to the treatment room and faces a fight against time to make the World Cup. He joins Zeki Celik, Marash Kumbulla and long-term absentee Georginio Wijnaldum on the sidelines once again.
Though Nicolo Zaniolo has been handed a three-match ban in the Europa League following his dismissal against Real Betis, the Italy forward is available on Sunday and should start in support of Tammy Abraham up front, with Andrea Belotti most likely relegated to the bench.
After being rested on Monday, Nemanja Matic's vast experience should win him the nod over Mady Camara in midfield.
Roma possible starting lineup:
Patricio; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Matic, Spinazzola; Pellegrini, Zaniolo; Abraham
Napoli possible starting lineup:
Meret; Di Lorenzo, Kim, Jesus, Rui; Ndombele, Lobotka, Zielinski; Lozano, Osimhen, Kvaratskhelia