On the other hand, the visitors will be aiming to exact revenge on their hosts following a 2-0 defeat in the reverse fixture back in September.
Match preview
Waalwijk were beaten 1-0 for the third game running as they just about came up short against Go Ahead Eagles at De Adelaarshorst on Saturday.
Henk Fraser's men fell behind to Jakob Breum's opener just after the hour mark and that proved to be the all-important moment in a tight affair.
As a result, RKC remain 16th in the Eredivisie table, three points shy of SBV Excelsior and a further two behind Heracles in what is shaping up to be an enthralling relegation battle.
Lying in store next is the challenge of an opposing outfit who boast just one win from the last six editions of this fixture across all competitions.
Having picked up just one win from their most recent eight matches either side of the New Year, Saturday's hosts will be keen to turn things around in front of their fans.
Vitesse were on the receiving end of a narrow 2-1 defeat against FC Twente when the sides went head-to-head at the GelreDome on Saturday evening.
Edward Sturing's men fell behind to Ricky van Wolfswinkel's early opener but managed to restored parity through a Robin Propper own goal before Joshua Brenet grabbed the winner 11 minutes from time.
With 16 points amassed from their 24 league matches so far, Geel en Zwart sit bottom but one in the standings, five points adrift of safety.
Off the back of recently ending an eight-game losing streak on the road, Sunday's visitors now go in search of consecutive wins away from home for the first time since July.
RKC Waalwijk Eredivisie form:
D
L
W
L
L
L
Vitesse Eredivisie form:
L
L
L
D
W
L
Vitesse form (all competitions):
L
L
L
D
W
L
Team News
Nouri El Harmazi remains out of action for Waalwijk as he continues to nurse a shoulder problem, which has seen him fail to feature this term.
Yassin Oukili was on target for the home side in the reverse fixture, and the 23-year-old will be looking to deliver the goods once again.
Fode Fofana and Miliano Jonathans are both ruled out through knee injuries, with the Dutch duo having made only a combined nine appearances this term.
Davy Propper also misses out for the visitors through a muscle injury, but the midfielder is drawing increasingly closer to making a comeback.
RKC Waalwijk possible starting lineup:
Vaessen; Meijers, Van den Buijs, Adewoye, Lelieveld; Oukili, Roemeratoe; Lokesa, Niemeijer, Cleonise; Min
Vitesse possible starting lineup:
Room; Arcus, Oroz, Hendriks, Pinto; Aaronson, Kozlowski, Meulensteen; Boutrah, Meerdink, Hadj Moussa