The teams come into this one off the back of their respective maiden league wins this term and will be looking to pick up where they both left off.
Match preview
Preston North End got their league campaign up and running with a narrow 1-0 victory over Luton Town at Kenilworth Road on Saturday afternoon.
Ryan Lowe's men opened the scoring early on through Brad Potts before putting on a solid defensive display to come away with all three points.
The Lilywhites are currently seventh in the league standings, level on points with Sunderland in the race for the last promotion playoff spot.
Coming up next is the task of facing off against an opposing outfit who have won each of the most recent three and are unbeaten in the last five meetings between the teams.
Ahead of mouth-watering clash against Watford this weekend, Tuesday's hosts will be seeking to set the time with a dominant display here.
Rotherham United claimed a resounding 4-0 victory over Reading when the sides went toe to toe at the Aesseal New York Stadium on Saturday.
First-half goals from Richard Wood, Conor Washington, Jamie Lindsay and Chiedozie Ogbene secure a well-deserved three points for Paul Warne's men.
Consequently, The Millers sit eight in the Championship table, just one point behind their next opponents albeit having played a game fewer.
Unbeaten in each of their last 10 outings on the road across all competitions, Tuesday's visitors now go in search of another feather in the cap away from home.
Preston North End Championship form:
Preston North End form (all competitions):
Rotherham United Championship form:
Rotherham United form (all competitions):
Team News
Preston North End's Bambo Diaby is set to miss a fifth consecutive game on the bounce due to a muscle injury which he picked up in pre-season.
The home side will also have to make do with the absence of Sean Maguire whose last appearance came back in late April after which he suffered a knee injury.
Midfielder Brad Potts has found the back of the net in each of his last two outings and will be looking to deliver the goods once again.
Benjamin Wiles was on target in the most recent encounter involving Tuesday's opponents, making the 23-year-old one to look out for here.
Joshua Kayode and Tom Eaves both remain sidelined for the visitors as they continue to nurse muscle and ankle problems respectively.
Preston North End possible starting lineup:
Woodman; Hughes, Lindsay, Storey; Potts, Whiteman, Browne, Brady, Ledson; Parrott, McCann
Rotherham United possible starting lineup:
Johansson; Hall, Wood, Humphreys, Lindsay, Ferguson; Harding, Wiles, Barlaser; Ogbene, Washington