The visitors, meanwhile, will head into the midweek encounter in a confident mood after losing just one of their last seven matches in League One.
Match preview
Portsmouth are currently leading the way at the top of the League One table after picking up 22 points from their opening 10 games.
Since salvaging a point with a late equaliser against Derby County on September 16, Pompey have embarked on a three-game winning run.
After beating Barnsley and Lincoln City, John Mousinho's side came from a goal down to beat 10-man Wigan Athletic thanks to efforts from Regan Poole and Paddy Lane.
The 2-1 win ensured Pompey have now gone 21 league games without defeat since losing 1-0 to Sheffield Wednesday in March.
That narrow defeat to the Owls also represents the one and only time Portsmouth have lost in Mousinho's 16 home league games as Pompey boss.
While Wycombe will have their work cut out to claim a positive result, they head into the midweek contest in fine form after winning four of their last five competitive matches.
The Chairboys recorded away wins over Bristol Rovers and Northampton, before beating Crystal Palace Under-21s in the EFL Trophy.
Although they were beaten 3-1 by Charlton Athletic on their most recent way trip, Wycombe bounced back with a 2-0 home win against Carlisle United on Saturday following a Luke Leahy penalty and a Sam Vokes effort.
That result extended Wycombe's unbeaten home league run to four games, while it also moved them onto 16 points to leave them in ninth position.
They will now turn their attention to Tuesday's encounter, and they will be confident about their chances of picking up at least a point after avoiding defeat in their last three meetings with Portsmouth (W1, D2).
Portsmouth League One form:
D
W
D
W
W
W
Portsmouth form (all competitions):
L
W
D
W
W
W
Wycombe Wanderers League One form:
D
W
W
W
L
W
Wycombe Wanderers form (all competitions):
L
W
W
W
L
W
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Team News
Mousinho recently confirmed that Anthony Scully is set to undergo knee surgery, which could keep him out for the remainder of 2023.
Portsmouth remain without the services of Kusini Yengi and Tom Lowery, while Conor Ogilvie is unlikely to feature after missing the last two games with an injury issue.
Pompey captain Marlon Pack is also a doubt after being forced off in the second half of Saturday's narrow victory over Wigan.
As for the visitors, they are still unable to call upon the injured trio of Jack Grimmer, Joe Jacobson and Jason McCarthy.
After claiming maximum points against Carlisle United, Wycombe boss Matt Bloomfield could be tempted to name an unchanged lineup.
Vokes, who netted his second goal of the season at the weekend, will resume his forward partnership with Brandon Hanlan.
Portsmouth possible starting lineup:
Norris; Rafferty, Poole, Shaughnessy, Sparkes; Morrell, Robertson; Lane, Saydee, Kamara; Bishop!-- TN -->
Wycombe Wanderers possible starting lineup:
Stryjek; Forino-Joseph, Keogh, Leahy; Pattenden, Scowen, Potts, Boyes; McCleary; Hanlan, Vokes
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