Meanwhile, the away side will be looking to record a fifth consecutive victory on the bounce and close out what has been an impressive season on a positive note.
Match preview
Needing to secure maximum points to keep their title chase alive, Porto made it win number 10 in a row across all competitions following a 4-2 triumph over Famalicao at Estadio Municipal de Famalicao on Saturday.
Sergio Conceicao's men raced to a commanding lead inside the opening 10 minutes through Mehdi Taremi's double but were pegged back before the half-time whistle thanks to strikes from Ivan Jaime and Santiago Colombatto, before Taremi grabbed a second-half double to settle matters.
While Azuis e brancos remain second in the Primeira Liga table, they have now moved within two points of league leaders Benfica, keeping their hopes of securing back-to-back league crowns alive.
Next up is the task of facing off against an opposing outfit who have lost each of the most recent eight meetings between the teams and boast just one win from the last 10 editions of this fixture.
Having come out on top in 14 of their 16 league matches on home turf this term, Saturday's hosts are huge favourites to get the job done in front of their fans once again.
Vitoria de Guimaraes continued their upturn in form by narrowly seeing off the threat of Gil Vicente in a 1-0 victory at Estadio Dom Afonso Henriques on Sunday.
With the scores level heading into second-half stoppage time, Anderson Silva popped up with a late winner to hand Moreno's men all three points in a tight affair.
Moving up to 53 points from 33 league outings so far, Os Vimaranenses sit fifth in the standings and are through to the playoff phase of the Conference League.
Off the back of a recent resurgence away from home which has seen them win consecutive matches for the first time since October, Sunday's visitors now brace themselves up for what is set to be a daunting assignment on the road.
Porto Primeira Liga form:
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Porto form (all competitions):
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Vitoria de Guimaraes Primeira Liga form:
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Team News
Porto's Joao Mario has missed eight matches on the spin due to injury, and the 23-year-old is not expected to back in time for Saturday's clash.
Following his four-goal haul last time out, Mehdi Taremi has overtaken Goncalo Ramos at the top of the scoring charts, leaving him on course to pick up the Golden Boot award.
Evanilson will be targeting an immediate return to the hosts' starting XI here after he was dropped to the bench in favour of Toni Martinez last time out.
Midfielder Andre has been ruled out of action with a muscle problem which he picked up in Vitoria de Guimaraes' 2-0 defeat against Sporting CP last month.
The away side will also be without the services of Celton Biai, who deputised in goal for Bruno Varela during his seven-week absence through a damaged shoulder.
Bruno Gaspar and Afonso Freitas were both forced off in the first half of the win over Gil Vicente, making their involvement this weekend doubtful.
Porto possible starting lineup:
Costa; Wendell, Cardoso, Pepe, Pepe; Franco, Eustaquio, Uribe, Galeno; Taremi, Evanilson
Vitoria de Guimaraes possible starting lineup:
Varela; Villanueva, Bamba, Amaro; Luz, T. Silva, Handel, Maga; J. Silva, A. Silva, Johnston