The hosts will head into the game seeking to get one over the visitors who they failed to pick up a point against in both home and away fixtures last term.
Match preview
Portimonense continued to drop points in the Portuguese top-flight as they were held to a 1-1 draw by a resilient Boavista side last Sunday.
In a cagey affair at the Estadio do Bessa, Carlinhos scored what was his first goal of the season on the stroke of half time to hand the Alvinegros a one-goal lead heading into the break, but Petar Musa came up clutch for Boavista when he stuck a 92nd-minute leveller to force a share of the spoils.
This followed a slender 1-0 home defeat at the hands of Pacos de Ferreira, where Douglas Tanque scored in the dying minutes of the first half to hand Os Castores their second win of the season.
While Portimonense have been solid at the defensive end of the pitch, where they have conceded three goals and kept two clean sheets, a lack of firepower in attack is a growing concern for head coach Paulo Sergio.
Friday's hosts have scored five goals from their opening five games this season, with three coming in the victory over Tondela a little under one month ago.
Next up is the daunting task of going against a Santa Clara side who they have failed to beat in the last six meetings between the teams, losing three and picking up three draws.
Santa Clara bounced back from their Conference League qualification heartbreak to secure their first Primeira Liga win when they saw off Gil Vicente 1-0 at the Estadio de Sao Miguel three weeks ago.
However, this resurgence was short lived as they were sent crashing back to earth in their subsequent outing as suffered a humbling 5-0 defeat at the hands of high-flying Benfica last Saturday.
After controlling proceedings for most of the first half, Rodrigo Pinho scored three minutes before the interval to open the floodgates for As Aguias, who hit four goals midway through the second half through Rafa Silva, Roman Yaremchuk and a brace from Darwin Nunez.
Daniel Ramos's men, who secured an impressive sixth-placed finish last campaign, have now failed to win four of their first five league games, picking up one draw and losing three.
This has been down to their struggles at the defensive end of the pitch which is a key area needing strengthening if they aim to get their season up and running as they have conceded the most goals so far in the division with 12.
Portimonense Primeira Liga form:
Portimonense form (all competitions):
Santa Clara Primeira Liga form:
Santa Clara form (all competitions):
Team News
Portimonense will take to the pitch without Brazilian forward Fabricio, who is currently recuperating from a knee injury he sustained in the game against Vitoria de Guimaraes back in August.
Newly-signed Shoya Nakajima continues to wait for his debut as he makes his long journey to full fitness after picking up a severe injury that has kept him out of action since February.
However, fellow newcomer Achraf Lazar could be handed his first appearance for the club after recently joining from Watford on a two-year deal.
Meanwhile, the visitors will still have to cope without the services of 26-year-old Brazilian Allano who will serve the second of a three-game suspension for picking up a straight red against Gil Vicente three weeks ago.
Venezuelan defender Mikel Villanueva picked up an injury while on international duty versus Peru last Monday and will sit out the game.
Costinha is another name on Santa Clara's injury list after the midfielder sustained an Achilles tendon injury in the game against Moreirense on August 15.
Ramos opted for a back three last time out to match Benfica's three-man defence but following his sides's underwhelming performance, we expect the Portuguese manager to revert to his preferred 4-2-3-1 formation.
Portimonense possible starting lineup:
Samuel; Moufi, Possignolo, Pedrao, Cande; Rocha; Fernandes, Carlinhos, Oliveira, Ewerton; Junior
Santa Clara possible starting lineup:
Fernandes; Ramos, Afonso, Henrique, Mansur; Carvalho, Morita; Costa, Lincoln, Patric; Cryan
We say: Portimonense 1-1 Santa Clara
Prediction justification text here