The visitors, meanwhile, are aiming to clinch consecutive victories after beating Ajaccio 1-0 in the league at the weekend.
Match preview
Partizan are currently unbeaten in their last nine competitive games, while they have scored 14 goals in their previous three games.
After beating Kolubara 5-1 in the league, Partizan were involved in a six-goal thriller in their opening Europa League group stage game against Slovacko.
A Fousseni Diabate brace and a Ricardo Gomes strike helped the Serbian outfit come from two goals down to take a 3-2 lead, but Libor Kozak's late equaliser ensured the contest remained a 3-3 draw.
Thursday's hosts continued their fine goalscoring form at the weekend with a comprehensive 6-0 victory over Mladost Lucani that ensures they are yet to lose at home this season.
After winning two and drawing three of their five competitive home games this term, Partizan will be confident of achieving a positive result against Nice.
Like their hosts, the Ligue 1 side also drew their opening group stage match, although their home meeting with Koln only produced two goals.
Andy Delort scored from the spot in the second half to cancel out Steffen Tigges's first half effort, ensuring Nice began their European campaign with a point.
The French outfit had Delort to thank once again at the weekend as it was the forward's goal that helped secure a narrow 1-0 victory over Ajaccio at the weekend.
Although Nice emerged victorious on Sunday, Lucien Favre has struggled in his return to the club, winning only three of his 10 competitive games this season.
Ahead of a midweek trip to Serbia, Nice can at least take confidence from the fact they have lost just one of their last four matches.
Partizan Europa Conference League form:
Partizan form (all competitions):
Nice Europa Conference League form:
Nice form (all competitions):
Team News
The hosts are unable to call upon the services of Danilo Pantic and Andrija Pavlovic, who are sidelined with injury issues.
Kristijan Belic will also miss out through suspension after being sent off against Slovacko, which will present Patrick Andrade with a starting opportunity.
After netting a hat-trick in the 6-0 win over Mladost Lucani at the weekend, Gomes has now scored seven goals in his last three appearances, and he will look continue his fine form when he partners Diabate in the forward line.
As for Nice, a hamstring injury will prevent Aaron Ramsey from featuring, while Youcef Atal is a doubt due to a thigh problem.
Joe Bryan dropped to the bench for Sunday's league win over Ajaccio, but the left-back could return to the starting lineup on Thursday.
Delort will provide the main goal threat for the visitors, with the forward looking to add to his four-goal tally for the season.
Partizan possible starting lineup:
Popovic; Markovic, Sanicanin, Vujacic; Zivkovic, Andrade, Traore, Urosevic; Natcho; Diabate, Gomes
Nice possible starting lineup:
Schmiechel; Lotomba, Todibo, Dante, Bryan; Pepe, Boudaoui, Thuram, Diop; Laborde, Delort