Meanwhile, the away side continue their quest for a European finish after returning to winning ways last time out.
Match preview
PSV failed to capitalise on Ajax's dropped points against AZ Alkmaar as they were held to a 2-2 draw by Feyenoord on Sunday.
Roger Schmidt's men stormed to a two-goal lead at half time thanks to a double from Cody Gakpo before Cyriel Dessers netted twice in the final 10 minutes to leave honours even at De Kuip.
As a result, the Rood-witten remain four points behind Ajax in the race for the Eredivisie crown with just two games left to play.
Coming up next is a clash versus an opposing outfit who have lost eight consecutive meetings between the teams dating back to 2013.
Having picked up 39 of a possible 48 points in front of their fans this term, Wednesday's hosts are firm favourites to close out their home campaign on a high.
NEC claimed a crucial 1-0 victory over Go Ahead Eagles when the sides faced off at Stade de Goffert on Sunday.
The game was decided in the fourth minute of second-half stoppage time as Ibrahim Cissoko grabbed a late winner for Rogier Meijer's men in Nijmegen.
The Eniesee have moved up to ninth spot in the league standings and are now behind the last European spot only on goal difference.
Irrespective of whether they can secure a place in the qualifiers of the Conference League playoffs, Wednesday's visitors can look back on their first top-flight season since 2017 with great pride.
PSV Eindhoven Eredivisie form:
PSV Eindhoven form (all competitions):
NEC Eredivisie form:
Team News
Pedro Ruiz is unavailable for NEC having recently undergone knee surgery, while Edgar Barreto also misses out through injury.
Cas Odenthal was fit enough to make the bench last time out, but it remains to be seen whether the defender will feature in this one.
Once again, PSV will be without the services of Shurandy Sambo and Ryan Thomas, who continue to nurse knee injuries.
Olivier Boscagli, Philipp Mwene and Armando Obispo are also on the hosts' treatment table, which became a man light last time out following Noni Madueke's return to action.
Meanwhile, Andre Ramalho and Yorbe Vertessen are both on the verge of making their comeback from ankle and groin injuries respectively.
PSV Eindhoven possible starting lineup:
Mvogo; Max, Gutierrez, Teze, Mauro; Sangare, Veerman; Gakpo, Gotze, Doan; Zahavi
NEC possible starting lineup:
Branderhorst; El Karouani, Guth, Marquez, Van Rooy; Schone, Proper; Tavsan, Bruijn, Okita; Akman
We say: PSV Eindhoven 4-1 NEC
PSV boast better players in every department of the field, and it is hard to envisage any other outcome than a win for them. We are tipping the hosts to cruise to a comfortable victory, scoring plenty of goals en route.
Data Analysis
Our analysis of all available data, including recent performances and player stats, suggests the most likely outcome of this match is a PSV Eindhoven win with a probability of 82.36%. A draw has a probability of 11.3% and a win for NEC has a probability of 6.31%.
The most likely scoreline for a PSV Eindhoven win is 3-0 with a probability of 10.42%. The next most likely scorelines for that outcome are 2-0 (10.28%) and 3-1 (7.99%). The likeliest drawn scoreline is 1-1 (5.18%), while for a NEC win it is 1-2 (1.99%).