On the other hand, the away side head into this one fresh off the back of their maiden league win of the current campaign last time out.
Match preview
PSV saw off the threat of newly-promoted Excelsior courtesy of an emphatic 6-1 victory at Van Donge & De Roo Stadion on Sunday afternoon.
Xavi Simons and Ibrahim Sangare grabbed two goals apiece, while Cody Gakpo and Joey Veerman were also on target for Ruud Van Nistelrooy's men.
The Rood-witten sit third in the Eredivisie table, a point behind second-place Feyenoord and a further two adrift of league leaders Ajax, albeit with one game in hand.
Their next task sees them face off against an opposing outfit currently on a run of 13 straight defeats in this fixture dating back to 1995.
Off the back of a disappointing defeat in their last home outing, Wednesday's hosts set out to return to winning ways on their own patch and move top of the league.
FC Volendam got their season up and running at the third time of asking following a narrow 1-0 victory over FC Twente at the Kras Stadion on Sunday.
Wim Jonk's men held on for their dear lives for major parts of the game before delivering a sucker punch through Lequincio Zeefuik in the 83rd minute.
As a result, Het Andere Oranje have moved up to 11th place in the league standings and are now just a single point away from the top half.
Aiming to improve their woeful away record of late which has seen them win just one of the last 10 games on the road, Wednesday's visitors have it all to do as they take on a more illustrious opponent.
PSV Eindhoven Eredivisie form:
PSV Eindhoven form (all competitions):
FC Volendam Eredivisie form:
FC Volendam form (all competitions):
Team News
Yorbe Vertessen remains ruled out with a muscle injury, and the Belgian is not expected to play any part for PSV Eindhoven in this one.
Marco van Ginkel and Noni Madueke are also sidelined with hamstring and ankle injuries respectively, while Mauro Junior is yet to fully recover from a groin problem.
Last season's player of the year Cody Gakpo has picked up where he left off with three goals and as many assists this term, making him one to look out for here.
Twenty-two-year-old Achraf Douiri made his return to action for Volendam last time out and will be pushing to retain his place in the starting XI.
Meanwhile, Calvin Twigt and Oskar Buur are currently down with knee problems with both player yet to feature for the away side since March.
PSV Eindhoven possible starting lineup:
Benitez; Max, Obispo, Ramalho, Teze; Gutierrez, Veerman, Sangare; Gakpo, Simons, Saibari
FC Volendam possible starting lineup:
Stankovic; Douiri, Plat, Mirani, Murkin; Benamar, Muhren, Eiting; Ould-Chikh, Veerman, Van Mieghem