Both sides are currently involved in a five-team battle for Dutch supremacy this season, and neither of them will want to come away empty-handed from this weekend's game.
Match preview
Despite a 2-0 victory against Sevilla on Thursday, PSV were dumped out of the Europa League having suffered a 3-2 aggregate defeat to their Spanish counterparts.
Second-half goals from Luuk de Jong and Fabio Silva gave Ruud van Nistelrooy's men a shot at overturning a three-goal first-leg deficit but it was too little, too late.
With little time to dwell on their continental calamity, the Rood-witten now turn their attention to league action, where they currently sit fourth in the Eredivisie table, six points off the top.
Awaiting them next is the task of facing off against an opposing outfit who have come out on top in just one of the last 17 meetings between the teams across all competitions.
However, that solitary victory came in the most recent clash back in September, when Sunday's hosts were beaten 2-1 in this season's reverse fixture.
Twente suffered a first league loss since October as they fell short to Go Ahead Eagles in the sides' encounter at De Adelaarshorst on Sunday afternoon.
Ron Jans's men made a slow start to the match and deservingly went two goals down inside the opening 16 minutes thanks to strikes from Philippe Rommens and Isac Lidberg.
Having picked up 40 points from 22 matches so far, the Tukkers are fifth in the standings and remain firmly in the hunt to qualify for European football.
Winless in eight matches on the road leading up to Sunday's contest, the visitors have it all to do in their bid to avoid yet another fruitless outing away from home.
PSV Eindhoven Eredivisie form:
W
L
W
D
W
D
PSV Eindhoven form (all competitions):
D
W
W
L
D
W
FC Twente Eredivisie form:
W
D
D
D
W
L
FC Twente form (all competitions):
D
D
D
L
W
L
Team News
Savio, Anwar El-Ghazi and Thorgan Hazard are all unavailable for PSV as they continue to battle with muscle problems which will see them miss Sunday's game.
Luuk de Jong scored for the fourth time in five matches last time out, and the forward will be keen to deliver the goods for his side once again.
Twente's Wout Brama remains sidelined with an ankle problem, and the Dutchman is yet to make an appearance since the second week of January.
Michal Sadilek has struggled with a niggling knock over the last couple of weeks, making the 23-year-old's involvement this weekend a huge doubt.
PSV Eindhoven possible starting lineup:
Benitez; Teze, Ramalho, Branthwaite, Van Aanholt; Veerman, Sangare, Simons; Bakayoko, De Jong, Saibari
FC Twente possible starting lineup:
Unnerstall; Smal, Bruns, Hilgers, Brenet; Steijn, Kjolo, Salah-Eddine; Misidjan, Cerny, Van Wolfswinkel