The Spanish side will have home advantage for the first leg, which takes place at the usually vociferous El Sadar.
Match preview
After spending 16 years away from UEFA competition, Osasuna are finally set to end their long wait for European football after finishing in seventh place last season.
There was doubt over the summer as to whether Jagoba Arrasate's side would be able to take their place on the European stage after they were initially banned by UEFA for a match-fixing scandal that took place in the 2013-14 season.
Osasuna subsequently submitted an appeal to the Court of Arbitration (CAS), arguing that the current administration had not been involved in the scandal and notified authorities when they were made aware of the irregularities.
Following a conciliation process overseen by CAS, UEFA decided to allow Los Rojillos to compete in the Europa Conference League this season, ensuring the Spanish side can now look forward to their first European game since losing to Sevilla in the semi-finals of the 2006-07 UEFA Cup.
Osasuna began the new campaign with an away win over Celta Vigo, but they will go into Thursday's contest off the back of a disappointing result after suffering a 2-0 defeat to Athletic Bilbao on Sunday.
After spending the last two seasons competing in the Champions League, Club Brugge have had to settle for Europa Conference League football this season following their fourth-place finish last term.
In contrast to Thursday's opponents, Club Brugge have already had to negotiate two rounds of qualifying, beating Danish outfit Aarhus 3-1 over two legs before cruising to a 10-2 aggregate victory over Icelandic side KA in the previous round.
Ronny Deila's charges enter Thursday's first leg in scintillating form after dismantling RWDM Brussels on Sunday to claim a commanding 7-1 win, representing their fifth consecutive win across all competitions.
Impressively, Club Brugge have scored at least five goals in each of their last four matches, highlighting the sort of firepower that Deila has at his disposal.
Club Brugge will now look to claim their first competitive away win against a Spanish side after failing to do so in their previous 13 attempts (D5, L8)
Osasuna form (all competitions):
L
W
L
W
W
L
Club Brugge Europa Conference League form:
W
L
W
W
Club Brugge form (all competitions):
L
W
W
W
W
W
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Team News
Osasuna are still unable to call upon long-term absentee Darko Brasanac, who is sidelined with an anterior cruciate ligament injury sustained in April.
Kike Barja, who has missed the opening two games of the La Liga season, has returned to training and could be passed fit to take up a place on the bench.
After enjoying a breakout season last term, Aimar Oroz will be key to Osasuna's efforts over the next two legs, and the 21-year-old midfielder will look to dictate Thursday's contest alongside Jon Moncayola and Lucas Torro.
As for the visitors, they will travel to Pamplona without the injured trio of Bjorn Meijer, Casper Nielsen, Chemsdine Talbi, Ferran Jutgla and Kamal Soweh.
Maxim De Cuyper could also miss out after being forced off at half time of Sunday's league win over RWDM with a back problem.
Having scored five goals in his opening three appearances of the new campaign, Andreas Skov Olsen will carry a real attacking threat from the right flank.
Osasuna possible starting lineup:
Fernandez; Pena, Catena, D. Garcia, Mojica; Moncayola, Torro, Oroz; R. Garcia, Gomez, Budemir
Club Brugge possible starting lineup:
Mignolet; Buchanan, Mechele, Spileers, Sabbe; Vetlesen, Onyedika; Skov Olsen, Zinckernagel, Nusa; Thiago