The Greek club will be welcoming Qarabag FK, who have won their four previous matches in all competitions, including their most recent outing in this competition.
Match preview
Olympiacos might be performing well in the Super League Greece at the moment, as they currently sit in third place, but the same cannot be said for their European performances.
Right now the Red-Whites are without a victory in the opening two Group G matches, which saw them beaten 2-1 by Nantes and then 3-0 against Freiburg.
The lack of goals is likely one of the most concerning factors for Olympiacos manager Michel, but his team showcased they are capable of finding the back of the net at the weekend.
Cedric Bakambu scored a brace against Atromitos in a 2-0 victory, which is a result that they will be hoping to replicate.
With four games remaining and only a six-point gap between themselves and the current table toppers, there is plenty for Olympiacos to compete for.
The same can be said for their opponents with Qarabag being in second place right now after one victory and a defeat in their first two games.
While Gurban Gurbanov's men were beaten 3-1 in their first outing of the competition, they followed that up by securing a win against Nantes.
Goals from Marko Jankovic, Abdellah Zoubir and Owusu Kwabena helped earn that 3-0 victory, highlighting the attacking qualities that Qarabag brings to the table.
That side of their game has only continued to grow stronger since then as Qarabag have scored 10 times in the two matches that followed.
A 7-1 win was followed by a 3-1 victory in the league, bringing a lot of confidence into the team heading into Thursday's outing.
Olympiacos Europa League form:
D
W
D
W
L
L
Olympiacos form (all competitions):
W
L
D
L
L
W
Qarabag FK Europa League form:
L
W
Qarabag FK form (all competitions):
D
W
D
L
L
W
Team News
Bakambu and Youssef El-Arabi have proven themselves to be great attacking threats throughout the season so far for Olympiacos, and both men will likely be in the starting lineup in midweek to reflect that.
Ui-Jo Hwang has been brought in on loan to the Greek club this season from Nottingham Forest, but he is currently out of action right now with an injury.
Kevin Madina is an injury concern still for the visitors, and he will likely not end up being featured in this match.
However, Jankovic could end up making his way back into the team after he was rested at the weekend, with his experience likely being something Qarabag want to call upon.
Olympiacos possible starting lineup:
Tzolakis; Vrsaljko, Cisse, Papastathopoulos, Reabciuk; M'Vila, I. Hwang, Vrousai, Masouras; El-Arabi, Bakambu
Qarabag FK possible starting lineup:
Mahammadaliyev; Vesovic, Mustafazada, Guseynov, Bayramov; Qarayev, Jankovic; Sheydayev, Kady, Zoubir; Kwabena
We say: Olympiacos 1-3 Qarabag FK
Olympiacos might be the team with more European experience on paper, but when it comes to the most recent results it is the visitors that have shown more confidence and quality.
Qarabag have great attacking skills which have been showcased across recent performances, and that should lead to them causing plenty of problems throughout this match.