The visitors head to the Estadio Marcelo Bielsa aiming to record a third win in four outings while their hosts seek to preserve their seven-game unbeaten run.
Match preview
Newell's Old Boys played out a second straight stalemate following a 1-1 draw against Platense at the Estadio Ciudad de Vicente Lopez on Sunday.
Javier Sanguinetti's men took the lead five minutes shy of half time thanks to Marcos Ledesma's own goal but they were pegged back eight minutes from time through Juan Esquivel's equaliser.
Nonetheless, La Lepra have moved up to top spot in the league table, clear of nearest challengers Gimnasia and Huracan by a point after the first seven round of matches.
Lying in store next is the task of taking on an opposing outfit who are yet to taste defeat in the last seven meetings between the teams.
However, Saturday's hosts have won seven of their last nine matches on home turf and will fancy themselves to turn their fortunes around against this weekend's visitors.
Racing Club claimed a third home win in a row following a 1-0 victory over city rivals Independiente at the Estadio Juan Domingo Peron on Sunday.
Fernando Gago's men opened the scoring in the ninth minute thanks to Gabriel Hauche and that was enough to secure all three points in a close affair.
Consequently, La Academia have climbed up to fourth place in the standings, two points behind this weekend's opponents ahead of the encounter in Rosario.
Having failed to win any of their last five outings on the road, Saturday's visitors have it all to do as they go in search of a first away victory since May.
Newell's Old Boys Argentine Primera Division form:
Racing Club Argentine Primera Division form:
Team News
Ramiro Sordo remains one to keep an eye on this weekend having netted four times in his last seven starts for Newell's Old Boys.
Pablo Perez is ruled out as the 36-year-old continues to nurse an ankle problem which has seen him sit out each of the last five games.
Racing Club's Enzo Copetti has found the back of the net in his last two away matches and will be looking to continue to his goalscoring exploits on the road.
Argentine midfielder Matias Rojas is a huge doubt for the visitors due to a muscle injury, while Mauricio Martinez misses out through a damaged knee.
Newell's Old Boys possible starting lineup:
Macagno; Campagnaro, Ditta, Lema, Velazquez, Jacob; Sordo, Sforza, Fernandez, Gonzalez; Garcia
Racing Club possible starting lineup:
Gomez; Mura, Sigali, Insua, Mena; Miranda, Moreno, Vecchio; Hauche, Copetti, Chanchalay