The hosts, meanwhile, are looking to clinch their second win of the season after taking six points from their opening five games.
Match preview
The hosts' early season has been dominated by draws, with three of their first five games finishing all square, including a midweek encounter against Strasbourg.
They entered Wednesday's contest in a confident mood after goals from Evann Guessand, Mostafa Mohamed and Moses Simon helped Nantes claim a 3-1 victory over Toulouse last weekend.
That confidence dissipated when Habib Diallo gave Strasbourg the lead in the first half as Nantes look set to lose for the second time this season, but a late equaliser from Mostafa Mohamed helped salvage a point.
Nantes will now turn their attention to Saturday's game where they will be aiming to avenge the 4-0 defeat that they suffered against PSG in the French Super Cup in August.
Ahead of Saturday's game, Antoine Kombouare's side will take confidence from the fact that they are unbeaten in their opening two home games.
Unlike their hosts, PSG have had no trouble winning matches, with four of their five games this season resulting in victory.
They cruised through their opening three matches by a combined 17-3 scoreline before Neymar scored from the spot to rescue a point against Monaco last weekend.
After dropping points for the first time this season, Christophe Galtier's side returned to winning ways in midweek with a comprehensive 3-0 win over Toulouse, with Neymar, Kylian Mbappe and Juan Bernat all getting on the scoresheet.
The midweek victory leaves PSG at the top of Ligue 1, but they are being matched by Lens and Marseille who also have 13 points to their name.
Having scored 15 goals in their three away league games this term, the visitors will be confident of extending their unbeaten run in Ligue 1 to 15 matches on Saturday.
Nantes Ligue 1 form:
Nantes form (all competitions):
Paris Saint-Germain Ligue 1 form:
F
Paris Saint-Germain form (all competitions):
Team News
The hosts are without Quentin Merlin and Moussa Sissoko due to calf and hamstring problems respectively, while Moses Simon is a doubt after missing the Strasbourg clash due to a muscle injury.
Fabio replaced Sebastien Corchia just after the hour mark in midweek, and the former Manchester United player could come into the starting lineup for Saturday's contest.
After scoring in the last two matches, Mostafa Mohamed will attempt to find the net for a third straight game when he leads the line against PSG.
As for the defending champions, they are unable to call upon the services of Presnel Kimpembe and Pablo Sarabia due to injury issues.
Carlos Soler and Fabian Ruiz have recently joined PSG, and the new signings could be included in the squad, although they are not expected to start Saturday's encounter.
With 15 league goals between them this season, Lionel Messi, Neymar and Mbappe will continue to operate in the front three for the visitors.
Nantes possible starting lineup:
Lafont; Fabio, Castelletto, Pallois, Appiah; Moutoussamy, Girotto; Guessand, Blas, Bamba; Mostafa Mohamed
Paris Saint-Germain possible starting lineup:
Donnarumma; Pereira, Marquinhos, Ramos; Hakimi, Verratti, Vitinha, Mendes; Messi, Neymar, Mbappe
We say: Nantes 1-3 Paris Saint-Germain
Although we expect Saturday's encounter to be closer than the Super Cup meeting, we still expect PSG to have enough quality to claim a comfortable victory over a Nantes side who have lost only one of their opening five league games.