The teams are currently separated by one place and one point in the league table ahead of what should be an enthralling affair.
Match preview
Cangzhou snapped a two-game losing streak courtesy of a 1-1 draw against Beijing Guoan at the Wuhua Hengpi Football Town on Saturday.
Svetozar Sapuric's men broke the deadlock early on through Shihao Piao before they were pegged back in the 84th minute by Yuning Zhang's penalty.
Despite dropping to 13th place in the Chinese Super League table, The Mighty Lions are now three points clear of the relegation zone.
Next up is a crunch clash versus an opposing side who have only won one of the last seven meetings between the teams dating back to 2017.
Off the back of two defeats in their last three outings on the road, Wednesday's visitors set out to turn things around away from home and record a first win since the opening weekend of the season.
Meizhou Hakka were beaten for the first time this term following a 1-0 loss to Tianjin Jinmen Tiger at the Olympic Sports Center Stadium.
Farley Rosa's 13th-minute strike proved to be all-important strike as Milan Ristic's men failed to find the back of the net for the second game running.
The Wuhua-based side are currently 12th in the standings and a defeat in their next outing would see them leapfrogged by their opponents.
Having failed to win any of their last five home games, Wednesday's hosts will be eager to end this barren streak in front of their fans and get themselves back on track.
Meizhou Hakka Chinese Super League form:
Cangzhou Mighty Lions Chinese Super League form:
Team News
Xueming Liang is a major doubt for this one after he was hauled off with an injury 32 minutes into Meizhou Hakka's loss to Tianjin.
Nunez Bravo had to make do with a place on the bench in the aforementioned game but a recall to the starting XI could be on the cards here.
Shihao Piao marked his return to action with a first-ever goal for Cangzhou last time out and the midfielder heads into Wednesday's game with the wind in his sails.
Twenty-one-year-old Xiangshuo Zhang will be pushing for a start in this one after making his debut for the season last time out.
Meizhou Hakka possible starting lineup:
Hou; Chen, Bravo, Dugalic, Liao; Shi, Kosovic; Yang, Henrique, Li; Vukanovic
Cangzhou Mighty Lions possible starting lineup:
Shao; Yang, Yang, Zhang; Piao, Lin, Zheng, Yang; Taty Maritu, Iskandar, Ma