The Red Devils suffered a 1-0 loss to Crystal Palace in the league on Saturday, while Galatasaray will enter the contest off the back of a 2-1 victory over Ankaragucu in Turkey's top flight, which has left them top of the division.
Match preview
The next crisis is never too far away for Man United, who have lost five of their opening nine matches in all competitions this season, including four of their first seven Premier League matches of 2023-24.
The Red Devils have made their worst start to a league season in 34 years, with Saturday's 1-0 reverse to Palace at Old Trafford leaving them down in 10th position in the table, boasting just nine points from seven matches.
Erik ten Hag's side did manage to record back-to-back wins over Burnley and Palace in the league and EFL Cup respectively after their 4-3 defeat to Bayern Munich in the Champions League on September 20, but they were unable to overcome a stern Palace outfit at Old Trafford last time out.
Man United are already playing catch-up in Group A due to their loss in Munich, and there is certainly pressure on Ten Hag to deliver a positive result on Tuesday, before the team switch their attention back to the Premier League, welcoming Brentford to Old Trafford on October 7.
Two wins would boost confidence ahead of the international break, but two defeats, or two disappointing results, would further increase the displeasure among the club's supporters.
Man United have faced Galatasaray on six previous occasions, leading the head-to-head two wins to one, while three of their meetings have finished all square; the two teams last met in the group stage of the 2012-13 Champions League, with the Red Devils winning 1-0 at Old Trafford but losing 1-0 in Turkey.
Galatasaray are competing in the group stage of the Champions League for the first time since the 2019-20 campaign, while they have not managed to progress to the knockout round of the competition since 2013-14.
The Turkish champions played out a 2-2 draw with Copenhagen in their opening match in Group A, with Sacha Boey and Tete both scoring in the final exchanges to secure a share of the spoils for the hosts in Istanbul.
Galatasaray are actually unbeaten in all competitions this season, while they have won six of their seven Super Lig matches this season, sitting at the top of the table on 19 points.
Okan Buruk's side will enter this match off the back of a 2-1 win over Ankaragucu in the league on Saturday, and they certainly have players that can hurt Man United, with Mauro Icardi making an excellent start to the campaign, while a certain Wilfried Zaha should have the chance to take on his former club.
Galatasaray have drawn three and lost seven of their previous 10 games against English opposition away from home, while they have lost 14 of their last 17 away games in the Champions League, but the Istanbul giants are unbeaten in their last 20 matches in all competitions.
Manchester United Champions League form:
L
Manchester United form (all competitions):
L
L
L
W
W
L
Galatasaray Champions League form:
Galatasaray form (all competitions):
W
W
D
W
W
W
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Team News
Man United will again be without the services of Aaron Wan-Bissaka, Luke Shaw, Lisandro Martinez, Tyrell Malacia, Kobbie Mainoo and Amad Diallo through injury on Tuesday night.
Jadon Sancho is also out, with the attacker still not training with the first team due to his fall-out with Ten Hag, but Antony could be back involved, having returned to the club following a leave of absence.
Sergio Reguilon missed out against Palace due to a minor injury, but he could make a timely return to the XI here at left-back, which may allow Sofyan Amrabat to move into central midfield alongside Casemiro.
Bruno Fernandes might switch out to the right for this match, with Mason Mount and Marcus Rashford also playing in support of Rasmus Hojlund, who netted against Bayern in the competition last time out.
Galatasaray, meanwhile, will again be without the services of Kazimcan Karatas through injury; Hakim Ziyech is also a major doubt for the visitors, having only been able to train individually on Sunday morning due to a knock.
Icardi is certain to lead the away side's line, with the 30-year-old managing 10 goals in 12 appearances in all competitions this season, and he is set to be supported by Dries Mertens and Kerem Akturkoglu.
If Ziyech is not passed fit, then Zaha could make the XI against his former club, with the Ivory Coast international on the scoresheet against Ankaragucu in the league on Saturday.
Davinson Sanchez is also in line for a starting role in the middle of the defence, while ex-Arsenal midfielder Lucas Torreira is set to feature in central midfield alongside Kerem Demirbay.
Manchester United possible starting lineup:
Onana; Dalot, Varane, Lindelof, Reguilon; Casemiro, Amrabat; Fernandes, Mount, Rashford; Hojlund
Galatasaray possible starting lineup:
Muslera; Boey, Sanchez, Bardakci, Angelino; Torreira, Demirbay; Zaha, Mertens, Akturkoglu; Icardi
We say: Manchester United 2-1 Galatasaray
This is a huge football match for Man United, and Galatasaray are certainly capable of causing more misery for the Red Devils on Tuesday night. However, under the lights at Old Trafford, and backed by a crowd that remain behind the manager, we are expecting the 20-time English champions to navigate their way to a huge three points.
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