The Red Devils advanced to the fourth round of the FA Cup after a 3-1 success over Everton on Friday night, while the Addicks overcame Lincoln City 2-1 in the third tier last time out.
Match preview
Going from hero to zero in the space of an hour, Everton centre-back Conor Coady went through all the emotions on Friday night, as Man United survived a brief scare to overcome the Toffees and book their place in the fourth round of the FA Cup.
Antony's quickfire opener preceded a howler from David de Gea, allowing Coady to level the scores with just 14 minutes on the clock, but the England international turned into his own net after the restart prior to Marcus Rashford's penalty deep into added time.
Also escaping a chested, albeit offside, Dominic Calvert-Lewin effort courtesy of a VAR review, Man United continue to fight for success on four fronts this season and have already battled past Aston Villa and Burnley to progress to the quarter-finals of the EFL Cup.
The five-time winners - who last went all the way in 2017 - suffered back-to-back semi-final exits to Manchester City in 2020 and 2021, and their last two quarter-final eliminations have come against sides in lower divisions, but very few will hold out hope of a giant killing here.
The Erik ten Hag revolution is gathering a head of steam, as Man United enter Tuesday's game aiming to stretch their winning streak in all competitions to six matches, and all eight of their last games at Old Trafford have ended in victory, with 21 goals in tow.
Having suffered a blow to their festive celebrations after an early FA Cup exit at the hands of Stockport County, Charlton instead continued their quest for an unlikely playoff place in the League One standings against Lincoln on Saturday and were rewarded for their first-half attacking guile.
Scott Fraser and Corey Blackett-Taylor struck before the half-time whistle for the Addicks, who limited their visitors to just the one goal through Daniel Mandroiu in the 76th minute as they made it back-to-back wins to open 2023, having seen off Portsmouth 3-1 on New Year's Day.
Dean Holden's crop remain rank outsiders when it comes to challenging for a coveted place in the Championship, languishing in 12th place and nine points adrift of the top six, but a slice of club history is on the line for the visitors to the Theatre of Dreams.
Indeed, Charlton have never progressed to the semi-finals of the EFL Cup in their 118-year history and have only ever reached the quarter-finals once before in the 2006-07 season, which ended in dismay as Wycombe Wanderers claimed a 1-0 victory.
Queens Park Rangers, Walsall, Stevenage and Brighton & Hove Albion have all fallen to Charlton's superiority in the 2022-23 EFL Cup, but only against Walsall did they not need a penalty shootout to progress, and the Addicks have lost all of their last 10 meetings with Man United.
Manchester United EFL Cup form:
W
W
Manchester United form (all competitions):
L
W
W
W
W
W
Charlton Athletic EFL Cup form:
W
W
W
W
Charlton Athletic form (all competitions):
L
W
D
L
W
W
Team News
The hosts' creator-in-chief Bruno Fernandes may have been in line for a rest this week anyway, but he will miss out through suspension after picking up two cautions in the tournament already, leaving Ten Hag slightly short of midfield options as Donny van de Beek awaits an update on the knee injury he suffered against Bournemouth.
Jadon Sancho is also absent as he continues his individual program, while centre-back Axel Tuanzebe is still recovering from an unspecified long-term issue. Loan signing Jack Butland is eligible to make his debut here, having not played for parent club Crystal Palace in the competition this term.
With Manchester City lying in wait for their next Premier League fixture, a heavily-altered XI could see the likes of Alejandro Garnacho, Anthony Elanga and Fred handed chances to impress from the first whistle.
Over at The Valley, Charlton midfielder Sean Clare missed the last-16 win over Brighton due to suspension but is available here, while goalkeeper Joe Wollacott is absent with a fractured finger.
Fellow shot-stopper Ashley Maynard-Brewer will also need a once-over after missing the win over Lincoln due to concussion protocol, while Diallang Jaiyesimi (hip) and Mandela Egbo (quad) are also in the infirmary.
Ex-Arsenal youngster Chuks Aneke could potentially make the squad as he battles back from a hamstring complaint, but Jayden Stockley will likely be relied upon to lead the line at Old Trafford.
Manchester United possible starting lineup:
Butland; Wan-Bissaka, Lindelof, Maguire, Malacia; Fred, McTominay, Eriksen; Elanga, Martial, Garnacho
Charlton Athletic possible starting lineup:
MacGillivray; Clare, Ness, Lavelle, Inniss, Sessegnon; Rak-Sakyi, Dobson, Morgan, Blackett-Taylor; Stockley
We say: Manchester United 2-0 Charlton Athletic
Discovering a taste for goals and affinity for clean sheets during the winter period, even a second-string Man United side should experience few obstacles en route to a place in the semi-finals.