The victors of this contest will book their place in the final and set up a showdown with either Brighton & Hove Albion or Manchester United, who face off in the second semi-final on Sunday.
Match preview
Man City have booked their place in the Champions League semi-finals for the third successive year courtesy of a 4-1 aggregate victory over Bayern Munich, including a 1-1 second-leg draw at the Allianz Arena on Wednesday night.
Erling Braut Haaland made amends for a first-half penalty miss when he slotted home the opening goal just before the hour mark to increase his goal tally for the season to a staggering 48, before Joshua Kimmich levelled the scores on the night with a converted penalty kick seven minutes from time.
Despite a few shaky spells against a fired-up Bayern side in the second leg, the Citizens managed to complete the job and keep their hopes of winning an impressive treble alive, with pivotal FA Cup and Premier League fixtures on the agenda for Pep Guardiola's side over the next week.
Before preparing for a top-of-the-table showdown with title rivals Arsenal in the Premier League next Wednesday, Man City are tasked with seeing off lower-league opposition in the form of Sheffield United if they wish to end a three-year run of failing to progress from the FA Cup semi-final stage.
Indeed, the Citizens have been beaten by Arsenal, Chelsea and Liverpool in the last three FA Cup semi-finals, but they will fancy their chances against the Blades on Saturday having won each of their last 21 domestic cup ties against teams from lower divisions, scoring 78 goals and conceding just 11 in the process - a 1-0 FA Cup fourth-round loss to Wigan Athletic in February 2018 was the last time City tasted defeat against lower-league opposition.
City have progressed past Chelsea, Arsenal, Bristol City and Burnley in the previous four rounds of this season's FA Cup by an aggregate score of 14-0, including a 6-0 quarter-final victory against the latter at the Etihad Stadium last month, and Guardiola's men could become the first team since Everton in 1965-66 to reach the FA Cup final without conceding a goal if they manage to keep a clean sheet on Saturday.
Sheffield United are on the cusp of securing promotion from the Championship after claiming a slender 1-0 home win over Bristol City on Tuesday night, courtesy of a second-half strike from Man City loanee James McAtee.
The Blades, who sit second in the second-tier standings, now require just one more victory to confirm their return to the Premier League as they sit seven points clear of third-placed Luton Town, who have played a game more and dropped points at Reading last time out.
Paul Heckingbottom's men will put Championship duties to one side when they compete in their first FA Cup semi-final for nine years this weekend, with the Blades seeking to pull off an almighty cup upset and become the first lower-division team to beat a top-flight club in the semi-finals since the 1991-92 campaign when Sunderland beat Norwich City 1-0 at Hillsborough.
Sheffield United have seen off Millwall, Wrexham, Tottenham Hotspur and Blackburn Rovers in the previous four rounds of this season's competition, beating the latter 3-2 in a thrilling quarter-final tie at Bramall Lane in which Man City loanee Tommy Doyle netted a dramatic 90th-minute winner.
The Blades head into Saturday's contest having lost each of their last five FA Cup semi-finals, most recently a 5-3 defeat against Hull City in 2013-14. Although their chances of reaching their first FA Cup final since 1936 are slim, a run of four victories in their previous four meetings with Man City in the competition provides a glimmer of optimism ahead of their trip to Wembley.
Manchester City FA Cup form:
Manchester City form (all competitions):
W
W
W
W
W
D
Sheffield United FA Cup form:
Sheffield United form (all competitions):
W
W
W
L
W
W
Team News
Man City defender Nathan Ake has emerged as a doubt after pulling up with a hamstring injury in the draw with Bayern, although the Dutchman is hopeful that the problem is "not too bad".
The Citizens have no other injury concerns, with Phil Foden available for selection after recovering from appendix surgery, although it remains to be seen whether the attacker is fit to start on Saturday, so Riyad Mahrez and Jack Grealish could occupy the wide areas from the off.
After revealing that his side are "exhausted" in midweek, Guardiola may consider making some changes to his first XI, with Aymeric Laporte expected to get the nod in defence if Ake is not deemed fit to feature.
Kyle Walker, Rico Lewis, Kalvin Phillips and Julian Alvarez will also be pushing to start, while cup goalkeeper Stefan Ortega is expected to begin between the sticks at the expense of first-choice shot-stopper Ederson.
As for Sheffield United, midfield duo McAtee and Doyle are both unable to strut their stuff on the Wembley turf as they are ineligible to face their parent club.
The Blades will also have to cope without Enda Stevens, Rhys Norrington-Davies, Ben Osborn, Rhian Brewster and Jack O'Connell due to injury, but Wes Foderingham is available for selection after serving a two-match ban and could return in goal at the expense of Adam Davies.
The absence of Doyle - who started against Bristol City - and McAtee will likely see Oliver Norwood start in centre-midfield alongside Sander Berge and John Fleck, while veteran striker Billy Sharp will push Oli McBurnie for a place up front alongside Iliman Ndiaye.
Manchester City possible starting lineup:
Ortega; Stones, Dias, Laporte; Lewis, Rodri; Mahrez, Gundogan, De Bruyne, Grealish; Haaland
Sheffield United possible starting lineup:
Foderingham; Ahmedhodzic, Egan, Robinson; Baldock, Berge, Norwood, Fleck, Lowe; McBurnie, Ndiaye
We say: Manchester City 3-0 Sheffield United
Having already cruised to victory over two Championship clubs in the previous two rounds of this year's FA Cup, Man City will be confident of success against a Sheffield United side who will be regarded as huge underdogs for Saturday's semi-final.