While the Citizens find themselves sitting fourth in the top-flight standings, the Eagles are languishing in 15th place and are beginning to look over their shoulders following a poor run of form.
Match preview
After ending their four-game winless run in the Premier League with a 2-1 victory at Luton Town last weekend, Man City preserved their 100% record in this season's Champions League when a much-changed side beat Red Star Belgrade 3-2 in their final Group G fixture on Wednesday.
Academy graduates Micah Hamilton and Oscar Bobb celebrated scoring their first senior goals for the Citizens, the former of whom found the net just 19 minutes into his full debut, while Kalvin Phillips was handed a rare start and scored his first goal for the club from the penalty spot five minutes from time, either side of Red Star strikes from Hwang In-beom and Aleksandar Katai.
Pep Guardiola's men have sailed through to the last 16 and completed the group stage with a perfect six wins from six matches, breaking a Champions League record in the process following their win in Serbia, and they now shift their focus back to the Premier League before jetting off to Saudi Arabia next week for the Club World Cup.
Man City's recent wobble in the Premier League has allowed Liverpool, Arsenal and surprise package Aston Villa to climb above the reigning champions in the table, with Guardiola's side now sitting four points adrift of the former at the summit after 16 games.
The Citizens still have plenty of time to turn their fortunes around, though, and they will be confident of success on Saturday as they are unbeaten in their last 18 top-flight games at the Etihad, while they have only lost two of their previous 16 league meetings with Crystal Palace, although both defeats during this run took place on home soil.
Crystal Palace appeared to be on course to claim a surprise victory over Liverpool and provide Man City with a boost in their title pursuit, as they were leading 1-0 against the Reds heading into the final 15 minutes of last weekend's encounter at Selhurst Park.
However, the 75th-minute dismissal of Jordan Ayew ultimately proved costly as the Eagles conceded twice in the closing stages to lose 2-1, with Mohamed Salah's equaliser - netted just a minute after Ayew's red card - followed by a 91st-minute winner from Harvey Elliott, condemning the hosts to their eighth league defeat of the season.
The pressure is beginning to mount on manager Roy Hodgson, who has seen his side picked up just five points from a possible 45 available over the last two-and-a-half months, but Palace are still seven points clear of the relegation zone and know that one win could see them climb to as high as 11th place.
Considering that Saturday's clash at Man City is followed by tricky top-flight encounters with Brighton & Hove Albion, Chelsea, Brentford and Arsenal, it is difficult to see Palace fans celebrating much success during the festive period, but the Eagles have history when it comes to pulling off upsets and they have reason to be optimistic heading to the Etihad.
Indeed, only Manchester United (three) have won more Premier League games at Man City than Palace (two) since Guardiola's arrival at the Etihad in 2016; the Eagles have scored four goals in their last two visits, with a 2-0 win in October 2021 followed by a 4-2 loss in August last year - a game in which they let a two-goal lead slip in the second half.
Manchester City Premier League form:
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Manchester City form (all competitions):
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Crystal Palace Premier League form:
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Team News
Man City duo Erling Haaland (foot) and Jeremy Doku (muscle) are both major injury doubts for this weekend and are more likely to return for the Club World Cup next week, while Kevin De Bruyne remains sidelined with a hamstring problem.
After making nine changes to his side for the midweek win over Red Star, Guardiola is expected to recall several of his first-team regulars against Palace, with goalkeeper Ederson and defensive quartet Kyle Walker, Ruben Dias, Nathan Ake and Josko Gvardiol all pushing to return at the back.
Rodri is expected to take Phillips's place in midfield, while Mateo Kovacic will hope to keep his starting spot in the engine room ahead of John Stones, Manuel Akanji and Rico Lewis, who all began in defence against Red Star.
Jack Grealish should shake off a knock sustained in midweek to start on the left flank, while Phil Foden, Bernardo Silva and Julian Alvarez are all set to return in the final third.
As for Crystal Palace, Sam Johnstone (calf), Jefferson Lerma (hamstring) and Odsonne Edouard (knee) all picked up injuries against Liverpool last weekend and will join Eberechi Eze, Rob Holding (both ankle), Dean Henderson, Jesurun Rak-Sakyi (both thigh) and Cheick Doucoure (Achilles) in the treatment room.
Jordan Ayew is suspended following his red card last weekend, while Tyrick Mitchell is a major doubt with a hip injury, so Nathaniel Clyne could be tasked with operating at left-back once again, joining Marc Guehi, Joachim Andersen and Joe Ward in the back four that is set to protect Remi Matthews in goal.
Michael Olise should be fit to start on the right flank, while Jean-Philippe Mateta, who scored from the penalty spot against Liverpool, is set to lead the line in the absence of Edouard.
Manchester City possible starting lineup:
Ederson; Walker, Stones, Dias, Ake; Kovacic, Rodri; Foden, Bernardo, Grealish; Alvarez
Crystal Palace possible starting lineup:
Matthews; Ward, Guehi, Andersen, Clyne; Richards, Ahamada, Hughes; Olise, Mateta, Schlupp
We say: Manchester City 2-0 Crystal Palace
Crystal Palace have frustrated Man City in the past and have already won in Manchester this season, beating Manchester United 1-0 in September, but it seems a tall order for Hodgson's out-of-form and depleted squad to pull off another upset on Saturday.
Man City may not be at full strength themselves, but they have coped without Haaland and Doku in their last two games, and Guardiola can rely on a number of his first-team stars, who were rested in midweek, to fire the champions to victory on home soil.