The relegation-favourites were thrashed 8-1 at the Allianz Arena by Bayern Munich last weekend, keeping them in huge danger of the drop this season.
Match preview
That annihilation at the hands of Bayern has greatly enhanced the odds of Mainz suffering relegation, potentially ending their 15-year stay in the top flight, as manager Bo Henriksen would likely take his place alongside the likes of Jurgen Klopp and Thomas Tuchel in Mainz folklore if he keeps the club up from this position.
Mainz have won just two of their 25 league games this season, and they remain nine points adrift of safety after last week's crushing defeat.
Upcoming opponents Bochum are the side they will be looking to target though, sitting just above the drop zone, and they can cut the gap to six points if they are to come out on top in this must-win encounter.
If that fails, Koln are not exactly pulling up trees in the relegation playoff spot, just two points ahead of Mainz, and that could be a way out for one of the three weakest sides in the Bundesliga to avoid the drop, rather undeservedly it must be said.
Conceding an xG of 6.6 last weekend suggests the pulverising defeat was wholly justified and did not flatter the Bavarians, giving Henriksen plenty to worry about both on the pitch, and mentally within the squad.
Bochum have often been kind opponents for Mainz though, as they have won both fixtures here since the two were reunited in the top flight back in 2022, and the hosts have won eight of their 11 all-time meetings in the Bundesliga.
That will be of great concern to a Bochum side who continue to falter since their headline-making win over Bayern last month.
Since the 3-2 success over Tuchel's side, bruising 5-2 and 4-1 defeats to Borussia Monchengladbach and RB Leipzig followed, respectively.
Their losing run was extended to three last weekend too, when Freiburg also went to the Ruhrstadion and left with all three points thanks to a 2-1 victory, despite the best efforts of Bochum to mount a late fightback.
Having gone eight games unbeaten at home dating back to September, back-to-back home defeats will come as a slight shock, and will leave Bochum looking over their shoulder slightly.
Bochum's defence has not been exactly watertight anywhere this season, but on the road it is particularly worrying, as Thomas Letsch's men have allowed 33 goals in 12 away games this season.
It is therefore no surprise that 365 days have passed since Bochum have beaten anybody that was not Darmstadt on the road, but bucking that trend here would go down extremely well with the club's hierarchy.
Mainz 05 Bundesliga form:
D
L
W
L
D
L
VfL Bochum Bundesliga form:
D
D
W
L
L
L
Team News
Nadiem Amiri scored the solitary Mainz goal in their 8-1 defeat last weekend, but the midfielder has missed training this week and is now doubtful for this one.
Amiri's midfielder partner Josuha Guilavogui has also been absent after a very scary moment at the Allianz, as the Frenchman was momentarily knocked unconscious after clashing with team mate Anthony Caci.
With Guilavogui stricken and motionless on the ground, referee Patrick Ittrich was quickly on hand to provide first aid, removing the player's tongue from his throat after the sickening collision, with a prognosis on the player's long-term condition not yet known.
With two midfielders potentially missing out, Henriksen will be glad to welcome back Leandro Barreiro Martins from suspension, while attacker Jessic Ngankam is also available after a ban of his own.
Bochum have been crippled by numerous injury issues of late, and just 45 minutes into his return last week, Tim Oermann suffered a recurrence of a hamstring issue and was forced off.
Momo Kwarteng has already been ruled out for the season with a knee injury, and the same problem will also see Matus Bero miss this clash.
Wide players Danilo Soares and Christopher Antwi-Adjei are two further names on the absentee list, with the pair suffering from muscular injuries at present.
Mainz 05 possible starting lineup:
Zentner; Van den Berg, Fernandes, Caci; Widmer, Barreiro Martins, Krauss, Mwene; Gruda, Burkardt, Lee
VfL Bochum possible starting lineup:
Riemann; Loosli, Ordets, Schlotterbeck, Bernardo; Asano, Daschner, Lossila, Stoger, Wittek; Broschinski
We say: Mainz 05 2-2 VfL Bochum
Recent form suggests Bochum will not be able to move towards the top half in the closing stages of the season, but maintaining the current healthy gap to the bottom three will do, and they should at least end their barren run here.