Meanwhile, the visitors are in impressive form, and they will attempt to claim a sixth consecutive victory in all competitions.
Match preview
MK Dons have struggled in their 12 league games, which have yielded only three wins and 10 points, leaving them in the relegation zone.
The hosts head into Saturday's contest off the back of three consecutive league defeats, while they have won only one of their last six games in League One.
After losing to Peterborough United and Shrewsbury Town, Liam Manning's side attempted to avoid another defeat last weekend when they played host to Bristol Rovers.
The contest appeared to be heading to a goalless draw, but Anthony Evans scored from the spot in the 76th minute to secure Bristol Rovers a 1-0 victory that leaves MK Dons one point adrift from safety.
Although MK Dons will be looking to return to winning ways on Saturday, three consecutive home defeats in League One suggest that claiming a victory over the league leaders may be a difficult task.
While MK Dons are involved in a relegation battle, Plymouth are currently one point clear of Ipswich Town at the top of the League One table, and they also have a five-point buffer to third-place Sheffield Wednesday.
Steven Schumacher's side are unbeaten in their last 11 league games, while 10 of those matches have ended in victory.
In their most recent encounter, goals from Niall Ennis, Sam Cosgrove and Ryan Hardie helped Plymouth claim a comfortable 3-0 win over Accrington Stanley.
Plymouth will attempt to record a sixth consecutive victory in all competitions this weekend, and they will be confident of doing so after scoring 11 goals and conceding on just three occasions in their last five competitive games.
As well as continuing their winning run, the visitors will also be aiming to maintain their record of scoring in every league game this season.
MK Dons League One form:
L
L
W
L
L
L
MK Dons form (all competitions):
L
W
L
W
L
L
Plymouth Argyle League One form:
W
D
W
W
W
W
Plymouth Argyle form (all competitions):
D
W
W
W
W
W
Team News
Zak Jules has started the last three league games for MK Dons, and the defender is set to retain his place in a back three alongside Dean Lewington and Warren O'Hora.
After coming off the bench to feature for the final half hour last weekend, Matthew Dennis could be presented with a starting place.
The 20-year-old is expected to be joined in a front two by Will Grigg, who will be looking to add to the three goals he has scored this season.
As for Plymouth, they will be without the services of Dan Scarr, who is suspended after being sent off against Accrington.
With Scarr unavailable, Schumacher could bring Nigel Lonwijk into the side to feature in a back three alongside Brendan Galloway and James Wilson.
After coming off the bench to score last weekend, Hardie could return to the starting lineup for Saturday's contest.
MK Dons possible starting lineup:
Cumming; O'Hora, Jules, Lewington; Oyegoke, Smith, Johnson, McEachran, Harvie; Grigg, Dennis
Plymouth Argyle possible starting lineup:
Cooper; Lonwijk, Wilson, Galloway; Whittaker, Randell, Houghton, Edwards; Hardie, Ennis, Cosgrove