The hosts find themselves two points clear of the drop zone with seven games remaining, while the visitors occupy ninth place in the Serie A table - 14 points above Lecce.
Match preview
It was always going to be difficult for Lecce to avoid this season's relegation battle after gaining promotion from Serie B last year, as the Puglia outfit were among the favourites to go straight back down.
A run of two losses in 11 games between November and February allowed Marco Baroni's men to dream of beating the drop, but the Giallorossi have failed to find a win since then.
In fact, Lecce have lost seven of their last eight matches while failing to score on six occasions, with last weekend's 2-0 defeat at AC Milan leaving the club just two points above the relegation zone.
Having managed to win only two of their previous 15 league outings - suffering nine defeats in the process - Lecce will need to turn the tide soon, with Hellas Verona and Spezia gathering momentum below.
Unfortunately for Baroni's men, they hold the third-worst home record in the division, having won just two of their 15 games at Stadio Via del Mare this term, so they could struggle to spark a revival on Friday.
Udinese appear to be finding their way again after enduring a damaging mid-season run of one win in 17 league matches, having kicked off their campaign with six victories across the first eight games.
The Bianconeri head into Friday's clash on the back of a comfortable 3-0 win over relegation-doomed Cremonese, with goals from Lazar Samardzic, Nehuen Perez and Isaac Success wrapping up the victory before half time.
Thanks to Sunday's triumph, Udinese have avoided defeat in six of their last eight league outings, with victories over Empoli and AC Milan preceding the demolition of Cremonese.
It is worth noting that no team has recorded more draws than Udinese's 12 this season, while only Napoli, Lazio, Juventus and Milan have suffered fewer defeats than Udinese's nine.
With sixth-placed Inter Milan leading ninth-placed Udinese by 12 points, Andrea Sottil's men would need a minor miracle to clinch European football, but they will back themselves to finish the season on a high note.
Lecce Serie A form:
L
L
L
L
D
L
Udinese Serie A form:
W
W
L
D
L
W
Team News
Leece are still without long-term injury absentees Kastriot Dermaku and Marin Pongracic, while Lorenzo Colombo is a doubt for Friday's game after missing the defeat at Milan last weekend.
Barcelona loanee Samuel Umtiti will continue to partner Federico Baschirotto at centre-back, with Morten Hjulmand anchoring the midfield.
Assan Ceesay is expected to lead the line for the hosts, with Lameck Banda and Federico Di Francesco likely to occupy the wide attacking roles.
As for Udinese, they will be without the injured duo of Gerard Deulofeu and Enzo Ebosse on Friday, while Simone Pafundi and Isaac Success are doubts.
Having chalked up four goals and eight assists this term, playmaker Roberto Pereyra is expected to operate behind Portuguese striker Beto, who has netted 10 Serie A goals in 2022-23.
Lecce possible starting lineup:
Falcone; Gendrey, Baschirotto, Umtiti, Gallo; Blin, Hjulmand, Oudin; Di Francesco, Ceesay, Banda
Udinese possible starting lineup:
Silvestri; Becao, Bijol, Perez; Ehizibue, Samardzic, Walace, Lovric, Udogie; Pereyra; Beto