While the home side currently occupy second position, Lincoln are only three points above the relegation zone in 18th place.
Match preview
Kieran McKenna's first full season as Ipswich boss has been a successful one so far, with only one of their 13 league games ending in defeat.
Since losing 2-1 to Plymouth Argyle on September 25, the Tractor Boys have responded by embarking on an impressive three-game winning run.
In their most recent outing, Ipswich came from behind to beat Morecambe 2-1 thanks to second-half goals from George Edmundson and Lee Evans.
As a result of their promising run of form, Ipswich are three points clear of third-placed Sheffield Wednesday, while they are only one point adrift of league leaders Plymouth.
The Tractor Boys will now turn their attention to Saturday's contest as they bid to maintain their unbeaten home record in the league this season.
While Ipswich are battling for promotion, Lincoln are looking to move away from the bottom four after collecting just 14 points from their opening 12 games.
The Imps began the season with one win in seven league matches, but they looked to have turned a corner when they claimed consecutive victories over Derby County and Bristol Rovers.
However, their last two matches have only yielded one point following a 2-0 defeat to Bolton Wanderers and a goalless draw against Charlton Athletic.
Lincoln are yet to lose at home in the league this season, but they head to Portman Road off the back of a poor run of away form.
Three of their last four away league games have ended in defeat, although their only win in that period was a sensational 6-3 victory over Bristol Rovers.
Ipswich Town League One form:
W
D
L
W
W
W
Ipswich Town form (all competitions):
D
W
L
W
W
W
Lincoln City League One form:
D
L
W
W
L
D
Lincoln City form (all competitions):
L
W
W
L
L
D
Team News
Ipswich are still without the services of Cameron Burgess, who has missed the last five league matches through injury.
Despite scoring last weekend, Edmundson's main priority will be on his defensive duties when he partners Richard Keogh in central defence.
After featuring as second-half substitutes against Morecambe, Wes Burns and Freddie Ladapo could come into the starting lineup for Saturday's contest.
As for the visitors, they will be unable to call upon Lewis Montsma who is still sidelined due to a knee injury.
After dropping to the bench for the goalless draw with Charlton, Jordan Garrick could return to the starting lineup on Saturday.
Ben House will retain his place in the forward line as the 23-year-old looks to add to the three goals that he has scored this season.
Ipswich Town possible starting lineup:
Walton; Donacien, Keogh, Edmundson, Davis; Evans, Morsy; Burns, Chaplin, Edwards; Ladapo
Lincoln City possible starting lineup:
Rushworth; Poole, Jackson, O'Connor; Eyoma, Sanders, Virtue, Roughan; Garrick, Diamond, House
We say: Ipswich Town 3-1 Lincoln City
Ipswich have been in impressive form this season, and we think that they will clinch a fourth consecutive victory when they face a Lincoln side who have lost three of their last four away league games.