Meanwhile, Vanuatu will be hoping to take advantage of a rare game against an established footballing nation by ending a three-match winless run.
Match preview
Although Guinea were certainly not one of the favourites to win the recent Africa Cup of Nations, they currently possess enough quality in their ranks where success was not totally out of the question.
Progressing through a group that featured Senegal and Cameroon proved that, and Kaba Diawara's side did enough in their last-16 clash with Equatorial Guinea to come through by a 1-0 scoreline.
However, despite taking a 1-0 lead against DR Congo in the quarter-finals, the National Elephants would ultimately succumb to a 3-1 defeat.
That meant that the wait for a first semi-final appearance since 1976 went on, Guinea having now suffered defeat in their last five quarter-final outings.
World Cup qualifying has already started, Guinea having already suffered defeat to Botswana, and Diawara may be grateful to take the next two friendlies to assess his options ahead of the resumption of that campaign in June.
International minnows Vanuatu are participating in their first game since reaching the semi-finals of the recent Pacific Games.
A 1-0 defeat came to eventual winners New Caledonia, yet Emerson Alcantara would have taken the positives from his team pushing them all the way.
Vanuatu currently sit in 170th position in the FIFA World Rankings, their only victories over the past 12 months coming against Fiji, Mongolia, Papua New Guinea and Tuvalu.
The fact that seven defeats have still been posted in 12 fixtures highlights the size of the task at hand here, regardless of the team selected by Diawara.
Guinea form (all competitions):
W
D
W
L
W
L
Vanuatu form (all competitions):
W
L
L
L
W
Team News
With another fixture against Bermuda to follow, it remains to be seen how many changes Diawara may make to his Guinea XI.
Of the players who did not start the AFCON last-eight tie, Saidou Sow, Ilaix Moriba and Serhou Guirassy will all be hoping for an opportunity to impress.
Mohamed Bayo could keep his spot down the middle of the attack, though, having scored against DR Congo.
Meanwhile, Alcantara will likely go with his strongest team possible in a bid to upset their more illustrious opponents.
Azariah Soromon is the star player in the Vanuatu side, scoring seven goals in his 17 international appearances.
Guinea possible starting lineup:
Kone; Diakite, Jeanvier, Diakhaby, Sylla; Keita, Diawara; Guilavogui, Camara, Sylla; Bayo
Vanuatu possible starting lineup:
Taiwia; M.Coulon, Philip, Ollie; Welwel, Moses, R.Coulon, Aru, Alick, Soromon; Tenene
We say: Guinea 3-0 Vanuatu
Although Guinea may not necessarily line up with their strongest side for this contest, it should still largely be one-way traffic. Vanuatu would take pride in a solid performance and avoiding a heavy defeat, and they may just avoid that here.