The home side are looking to pick up a fourth win on the bounce while the visitors go in search of a first victory in seven matches across all competitions.
Match preview
Godoy Cruz secured safe passage into the last 16 of the Copa Argentina thanks to an emphatic 3-1 triumph over Lanus on Wednesday evening.
Rodolfo Diego Flores's men conceded a 24th-minute opener to Franco Orozco before second-half goals from Tadeo Allende, Salomon Rodriguez and Martin Ojeda turned the tie on its head.
Prior to that, El Bodeguero saw off the threat of River Plate in a 2-0 victory which saw them move up into fifth place in the league table.
Coming up next is the challenge of an opposing outfit who have only lost one of the last five meetings between the teams dating back to 2019.
Having won each of their last five matches on home turf, Sunday's hosts will head into this weekend's clash with the wind in their sails and rightly so.
Lanus just about came up short in a thrilling 3-2 contest against an in-form Huracan side at the Estadio Nestor Diaz Perez on Sunday.
Goals from Braian Aguirre and Mateo Sanabria saw Jorge Almiron's men head into the interval with a narrow 2-1 lead but strikes in the second period from Benjamin Garre and Matias Coccaro completed a remarkable turnaround.
As a result, El Granate have dropped to 27th place in the standings and remain just a point ahead of bottom club Aldosivi after seven rounds of matches.
Off the back of four straight defeats and a seven-game winless run away from home, Sunday's visitors have it all to do as they aim to improve their fortunes on the road.
Godoy Cruz Argentine Primera Division form:
Godoy Cruz form (all competitions):
Lanus Argentine Primera Division form:
Lanus form (all competitions):
Team News
Tadeo Allende and Salomon Rodriguez both came off the bench to good effect against Lanus and they could be rewarded with starts here.
Martin Ojeda has now found the back of the net in consecutive games for Godoy Cruz, making the Argentine forward one to keep an eye on.
Gianluca Ferrari is set to serve a one-game suspension following his sending-off against River Plate for two bookable offences.
Twenty-year-old Franco Orozco will be looking to pick up where he left off having grabbed his first goal for the senior team last time out.
Pedro de La Vega remains without an appearance this season and the forward is not expected to play any part in this weekend's contest.
Godoy Cruz possible starting lineup:
Rodriguez; Negri, Barrios, Breitenbruch, Ortiz; Andrada, Abrego; Ojeda, Bullaude, Allede; Rodriguez
Lanus possible starting lineup:
Monetti; Aguirre, Perez, Braghieri, Aude; Perez, Loaiza, Careaga; Orozco, Sand, Sanabria