Meanwhile, the home side go in search of a third consecutive win on home turf where they have been a real force to reckon with since their promotion.
Match preview
PSV Eindhoven saw their 100% start to the campaign come to an end on Sunday when they were humbled 4-0 by Feyenoord in front of their own fans.
Jens Toornstra was the star of the show where he netted twice in a game where Bryan Linssen and Cyriel Dessers also hit the back of the net.
As a result, the Rood-Witten have now slipped into second place on the standings, one point behind current leaders and defending champions Ajax.
Roger Schmidt's men will hope to get back on track against an opponent who have lost each of the previous six meetings between the sides dating back to 2013.
Wednesday's visitors have scored at least three goals in all of those matches and an opportunity to run riot once again is on the horizon.
Fresh off the back of a disappointing 5-2 loss to Cambuur, Go Ahead Eagles saw off the threat of PEC Zwolle in a 1-0 win on Sunday to pick up their second victory of the season.
With the scores level heading into the final 10 minutes of normal time, Giannis-Foivos Botos popped up with the game's decisive moment to hand Kees Van Wonderen's men all three points.
The pride of the IJssel Kowet have climbed into the top half following their most recent victory in what has been a decent start to their first top-flight season in five years.
However, Wednesday's fixture is by far the hosts' biggest task to date and it will be interesting to see how they rise to the occasion.
Go Ahead Eagles Eredivisie form:
Go Ahead Eagles form (all competitions):
PSV Eindhoven Eredivisie form:
PSV Eindhoven form (all competitions):
Team News
Roger Schmidt is expected to make a couple of alterations to his regular starting XI in a bid to spark a reaction following the humbling defeat to Feyenoord.
The likes of Ryan Thomas and Yorbe Vertessen came off the bench in the aforementioned but could be handed a starting appearance this time around.
Scottish midfielder Frank Ross still awaits his first outing of the new campaign due to a knee injury he sustained earlier in the year.
Thirty-seven-year-old forward Jacob Mulenga is battling with a muscle injury which saw him play no part in the victory against Zwolle last time out.
Go Ahead Eagles possible starting lineup:
Hahn; Kuipers, Kramer, Nauber, Deijl; Brouwers, Lucassen, Rommens; Berden, Heil, Cardona
PSV Eindhoven possible starting lineup:
Mvogo; Max, Obispo, Ramalho, Teze; Boscagli, Van Ginkel, Thomas; Doan, Zahavi, Bruma
We say: Go Ahead Eagles 0-4 PSV Eindhoven
PSV will be be expected to give an immediate response to last week's loss at a venue where visiting teams have not had much joy this term. Nonetheless, we fancy the away side to come out on top in a comfortable manner, grabbing plenty of goals en route.