Die Mannschaft suffered a dampening 1-0 defeat to Poland in their most recent exhibition game, while the visitors overcame Iraq by the same scoreline.
Match preview
Had it not been for an exemplary display from Poland number one Wojciech Szczesny in between the sticks, Germany could have come away from Warsaw with more to show for their efforts on Friday, but the game will ultimately go down as another blot on Flick's notebook.
Following a guard of honour for Poland veteran Jakub Blaszczykowski as he left the field 16 minutes into his farewell appearance, centre-back Jakub Kiwior headed in his first goal for his country only a couple of weeks after opening his Arsenal account - not a half-bad month for the 23-year-old.
Poland subsequently faced an onslaught of Germany attacks in the hour that followed, but Szczesny stood tall time and time again to deny Die Mannschaft, whose preparations for next year's home European Championships can hardly get much worse.
Also being forced to come back from two goals down to draw with Ukraine and losing 3-2 to Belgium in March, Germany are ostensibly struggling to find their feet in Flick's new setup, and four wins from their last 15 games in all tournaments is abysmal for a nation of their calibre.
However, Flick has been given a public vote of confidence by Mannschaft director Rudi Voller - who clearly feels that it is not the time to press the panic button just yet - and the hosts can at least take confidence from the fact that they have scored in 13 successive home friendlies since drawing a blank against Brazil in March 2018.
In stark contrast to Flick, newly-appointed Colombia boss Nestor Lorenzo has masterminded a magnificent run of results at the Colombia helm since his predecessor Reinaldo Rueda tried and failed to lead his side to the Qatar World Cup.
Over the past 12 months, Colombia have not engaged a single competitive fixture but have strung together an eye-catching eight-game unbeaten run in friendly matches, beating the likes of Japan and Mexico while shaking hands on a point with the USA and South Korea.
Lorenzo's men most recently locked horns with Iraq at Valencia's Mestalla Stadium on Friday and came away with a 1-0 triumph courtesy of Mateo Cassierra's second-half winner, extending their unbeaten streak across all tournaments to 10 matches, having picked up a pair of inconsequential wins over Bolivia and Venezuela to round off their failed World Cup 2022 qualifying campaign.
Once Tuesday's game is done and dusted, preparations will commence for the CONMEBOL World Cup 2026 qualifying competition - which begins in September for La Tricolor - but for now, Lorenzo will somehow seek to make it seven games without defeat since taking the Colombian reins.
While the form book makes for pleasant reading for Colombia, the historical records do not, as they have lost two and drawn two of their previous four fixtures with Germany, who cruised to a 3-0 friendly success during the teams' last friendly showdown 17 years ago.
Germany friendly form:
W
L
D
L
Germany form (all competitions):
D
W
W
L
D
L
Colombia friendly form:
D
W
W
Colombia form (all competitions):
W
W
D
D
W
W
Team News
Germany boss Flick welcomed Champions League finalists Robin Gosens and Ilkay Gundogan back to the fold with open arms for the trip to Poland - two timely returns after Lukas Klostermann and Timo Werner both withdrew due to injury.
Gosens and Gundogan should both come into contention for starting roles as Flick shuffles his pack once more, with the former replacing Benjamin Henrichs while Gundogan potentially offers Joshua Kimmich a rest in the middle of the park.
Leroy Sane, Niclas Fullkrug, Matthias Ginter and Leon Goretzka could also benefit from some necessary rotation, and after witnessing Kevin Trapp and Marc-Andre ter Stegen take to the field against Ukraine and Poland respectively, Fulham's Bernd Leno will seek to earn just his 10th cap for the senior team.
As for Colombia, Lorenzo's men came through their recent success over Iraq unharmed, and the Tricolor head coach ought to persist with the 4-2-3-1 shape that has worked to great effect so far.
Despite his downturn in fortunes with Tottenham Hotspur, Davinson Sanchez is set to get the nod at the back, while Liverpool's Luis Diaz takes his rightful place on the left flank.
Cassierra's strike may not be enough to earn him a start over Rafael Borre, who has big shoes to fill in the shape of the absent Radamel Falcao - one of three Tricolor greats to miss out alongside David Ospina and James Rodriguez.
Germany possible starting lineup:
Leno; Ginter, Rudiger, Schlotterbeck; Wolf, Gundogan, Goretzka, Gosens; Sane, Musiala; Fullkrug
Colombia possible starting lineup:
Montero; Munoz, Sanchez, Lucumi, Machado; Uribe, Lerma; Cuadrado, Carrascal, Diaz; Borre
We say: Germany 2-1 Colombia
There will seemingly be no quick fix for Germany's defensive problems, and a free-scoring Colombia side should no doubt capitalise on their hosts' recent lapses at the back.