Victory at Stadio Luigi Ferraris would take the Grifone level on points with their visitors, who were well beaten by Roma last time out.
Match preview
Although they were ultimately edged out by Inter Milan earlier this week, Genoa put up a commendable fight at San Siro, where the league leaders have been swatting aside all-comers for several weeks now.
After conceding twice just before the break, the Grifone then pulled one back through Mexican defender Johan Vasquez, but they could not quite capitalise on several half-chances and suffered just a second defeat in 12 Serie A matches.
Nevertheless, Genoa's tally of 33 points is their best at this stage of a top-flight campaign since 2014, and last year's Serie B runners-up are still aiming to claim a top-10 finish in May.
Having only lost back-to-back league games once since gaining promotion, Alberto Gilardino's side will now expect to take more points from a home game against opponents sitting just above them in the table.
Looking back into the history books, Genoa have not lost even one of 26 previous home matches versus Monza - winning 20 and drawing six - so precedent is certainly on their side this weekend.
They may be yet to taste victory over Saturday's hosts at Marassi, but Monza did win December's reverse fixture 1-0 and recently broke new ground by beating near neighbours AC Milan for the very first time.
Unbeaten in five matches, including that history-making defeat of Milan, the Biancorossi hosted Roma last weekend, with real hope of extending their streak without defeat.
However, the resurgent Romans strode to a 4-1 win by scoring twice in either half, and Andrea Carboni's late strike was nothing more than a minor consolation.
Over the past six matchdays, Raffaele Palladino's men have still tallied as many points as reigning champions Napoli and third-placed Milan, so they remain within a whisker of Serie A's top 10, having finished 11th on their top-flight debut last term.
Monza have not conceded a goal in either of their last two away games, against Udinese and Salernitana, so Palladino will demand a return to such solidity after last week's aberration.
Genoa Serie A form:
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Monza Serie A form:
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Team News
In addition to scoring Genoa's goal in Monday's loss to Inter, Johan Vasquez also picked up another booking, which will see him sit out Saturday's contest through suspension; Alessandro Vogliacco is likely to deputise in the hosts' back three.
Defensive duo Ridgeciano Haps and Alan Matturro are also unavailable to Alberto Gilardino, who may name an otherwise unchanged starting XI.
Joining Italy striker Mateo Retegui up front, Albert Gudmundsson is the Grifone's leading scorer (nine goals), top chance-creator (63) and most successful dribble-completer (37) in Serie A this season.
Monza, meanwhile, can welcome Armando Izzo back from a one-match ban, but long-term absentee Gianluca Caprari again joins Samuele Vignato on the sidelines.
Biancorossi boss Raffaele Palladino recently switched to a back four, behind which Michele Di Gregorio will provide the visitors' last line of defence. The much-admired goalkeeper would reach 50 clean sheets for Monza by shutting out Genoa this weekend.
Genoa possible starting lineup:
Martinez; De Winter, Bani, Vogliacco; Sabelli, Frendrup, Badelj, Messias, Martin; Gudmundsson, Retegui
Monza possible starting lineup:
Di Gregorio; Birindelli, Mari, Izzo, A. Carboni; Pessina, Gagliardini; V. Carboni, Colpani, Mota; Djuric