While the home side currently sit in 10th position in the Turkish Super Lig, the visitors are in second position - level on points with the league leaders Istanbul Basaksehir.
Match preview
Gaziantep surged out of the blocks to begin their campaign with three wins and one draw, but their four-game unbeaten start has quickly been forgotten.
They head into Friday's game in the midst of a four-game winless run, which has included three defeats that leave them in midtable.
As they attempt to end their poor run of form, Friday's hosts will also look to avoid a third consecutive defeat after losing to Trabzonspor and Kasimpasa in their previous two games.
Although their recent results leave a lot to be desired, all three of their losses this season have taken place on their travels, suggesting Gaziantep are a different force on home turf.
Including last season, Gaziantep are unbeaten in their last 10 home league games, while their three home matches this term have yielded seven points.
Meanwhile, Adana Demirspor are six points better off than their hosts after winning five of their eight league games.
They are also unbeaten in their previous five matches since losing 4-2 away to Fenerbahce on the third matchday of the Turkish Super Lig season.
Despite enjoying a promising run of results, Adana Demirspor missed out on the chance to claim a third consecutive victory last weekend.
Following victories over Trabzonspor and Antalyaspor, Vincenzo Montella's side entered Saturday's home meeting with Galatasaray in a confident mood, but they had to be content with a point with neither side able to find a winner in a goalless draw.
Having failed to find the net for the first time this season, Adana Demirspor will attempt to discovered their goalscoring form this weekend as they look to claim consecutive away victories.
Gaziantep Turkish Super Lig form:
W
W
L
D
L
L
Adana Demirspor Turkish Super Lig form:
L
W
D
W
W
D
Team News
Gaziantep are without the services of Mustafa Eskihellac, who has missed the last two matches through injury.
Abdulkadir Parmak made his return from injury as a second half substitute in the 1-0 defeat to Kasimpasa, and he could be given a starting place for Friday's contest.
Meanwhile, Joao Figueiredo could also come into the side, with the forward looking to add to the four goals he has scored this season.
As for the visitors, they are without Benjamin Stambouli, who is suspended after being sent off in the goalless draw against Galatasaray.
With Stambouli unavailable, Gokhan Inler is set to come into the starting lineup to feature in a defensive midfield pairing alongside Badou Ndiaye.
Younes Belhanda has been operating as a forward in recent games, and he is expected to retain his place in the frontline for the meeting with Gaziantep.
Gaziantep possible starting lineup:
Guvenc; Kitsiou, Ersoy, Tosca, Hanousek; Parmak, Jevtovic; Markovic, Maxim, Sagal; Figueiredo
Adana Demirspor possible starting lineup:
Ozbir; Svensson, Akaydin, Guler, Rodrigues; Inler, Ndiaye; Sari, Akaba, Onyekuru; Belhanda