Meanwhile, the away side make the journey to Istanbul aiming to get back to winning ways having seen their two-game winning run come to an end last time out.
Match preview
Galatasaray were dumped out of the group stages of the Champions League following a 1-0 defeat to FC Copenhagen at the Parken Stadium on Tuesday.
Okan Buruk's men fell behind to Lukas Lerager's opener just shy of the hour mark and that turned out to be the all-important moment in a tight affair.
Prior to that, The Lions claimed a 3-1 win over Adana Demirspor which saw them remain level on points with city rivals Fenerbahce at the top of the Turkish Super Lig table.
Awaiting them next is the challenge of an opposing outfit who are without a win in the five most recent editions of this fixture after winning the first-ever encounter.
Ahead of a tantalising clash against Fenerbahce four days later, Wednesday's hosts will be keen to set the tone with a dominant display in front of their fans.
Fatih Karagumruk were on the receiving end of a 2-1 loss against Antalyaspor when the teams locked horns at Corendon Airlines Park two Saturdays ago.
Shota Arveladze's men conceded quickfire goals to Veysel Sari and Adam Buksa after which Guven Yalcin pulled one back on the stroke of half time.
With 23 points picked up from their 15 matches so far, The-Black-and-Red sit seventh in the standings, three points adrift of the last European spot.
Currently on a run of one win in seven matches away from home, Wednesday's visitors have it all to as they look to avoid another fruitless outing on the road.
Galatasaray Turkish Super Lig form:
W
W
L
W
W
W
Galatasaray form (all competitions):
L
W
D
W
W
L
Fatih Karagumruk Turkish Super Lig form:
D
D
W
L
W
L
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Team News
Davinson Sanchez recently made his return to action from a brief injury layoff for Galatasaray and is set to retain his place in the XI.
Having racked up 12 goals and five assists so far, Mauro Icardi has been directly involved in more goals than everybody else in the division, making him one to keep an eye on.
Karagumruk's Ibrahim Dresevic is now eligible to play a part here after serving a one-game suspension in the defeat to Antalyaspor.
This could see Frederic Veseli return to the starting lineup off the back of a rare start for the Albanian defender last time out.
Galatasaray possible starting lineup:
Muslera; Yilmaz, Bardakci, Nelsson, Boey; Demirbay, Torreira; Mertens, Akturkoglu, Tete; Icardi
Fatih Karagumruk possible starting lineup:
Dituro; Mercan, Ceccherini, Dresevic, Biraschi; Feghouli, Eysseric, Rohden; Keles, Yalcin, Mendes