Adana Demirspor, meanwhile, will be looking to claim a second straight win after beating Antalyaspor in their last outing.
Match preview
Excluding the awarded 3-0 win over Gaziantep, Galatasaray had claimed 13 consecutive league victories before they faced Konyaspor earlier this month.
Galatasaray took the lead through Milot Rashica before Soner Dikmen restored parity, and Konyaspor completed the turnaround in the 93rd minute when Ogulcan Ulgun grabbed the winning goal to condemn Okan Buruk's side to a 2-1 defeat.
The hosts head into the weekend with a six-point lead over second-placed Fenerbahce, who have a game in hand over Galatasaray.
With Fenerbahce not in action this weekend, Galatasaray have the chance to extend the gap at the top to nine points, and their impressive home record suggests that they have every chance of doing just that.
Since losing to Giresunspor in August, Galatarasay have dropped just two points in 11 home league games, with their last eight resulting in victory.
While Galatasaray are looking to win their 23rd Turkish Super Lig title, fourth-placed Adana Demirspor are aiming to qualify for the Europa Conference League.
After suffering a heavy 4-1 defeat away to Trabzonspor, Vincenzo Montella's side returned to winning ways in their home meeting with Antalyaspor.
Emre Akbaba opened the scoring for his side against Antalyaspor, before Cherif Ndiaye doubled Adana Demirspor's advantage to wrap up a 2-0 victory.
Having lost just one of their last eight league games, Adana Demirspor are in the hunt for a Europa Conference League place with four points separating them from the top three.
If they are to secure European qualification, Saturday's visitors will need to improve on their travels after winning just one of their previous seven away matches in the top flight.
Galatasaray Turkish Super Lig form:
W
W
W
W
W
L
Adana Demirspor Turkish Super Lig form:
W
D
D
W
L
W
Team News
Galatasaray will be without the services of Berkan Kutlu, who will serve a one-match suspension for an accumulation of yellow cards.
Yusuf Demir has missed the last two league games through injury, but after featuring in a club friendly against Qarabag during the international break, he is expected to take up a place on the bench.
After being suspended for the defeat to Konyaspor, Victor Nelsson will return to the backline to partner Abdulkerim Bardakci in central defence.
As for the visitors, they are still unable to call upon Younes Belhanda, who will miss a second straight game through suspension.
After beating Antalyaspor 2-0 in their most recent outing, Montella could be tempted to name an unchanged lineup on Saturday.
Ndiaye has top-scored for Adana Demirspor in the Turkish Super Lig this season, and he will be looking to add to his seven league goals.
Galatasaray possible starting lineup:
Muslera; Boey, Nelsson, Bardakci, Dubois; Torreira, Oliveira; Zaniolo, Rashica, Akturkoglu; Icardi
Adana Demirspor possible starting lineup:
Ozbir; Svensson, Cetin, Guler, Rodrigues; Sari, Stambouli, B. Ndiaye, Akintola; C. Ndiaye, Akbaba