On the other hand, the away side will be looking to arrest a slump in form which has seen them fail to win any of their last three outings.
Match preview
FC Twente put an end to their two-game losing streak with a thrilling 3-3 stalemate against Heerenveen at De Grolsch Veste on Saturday night.
After going behind to Mees Hilgers's own goal, Ron Jans's men hit back through Robin Propper, Manfred Ugalde and Vaclav Cerny to take a 3-1 lead, before Milan van Ewijk and Rami Kaib both netted in a 30-minute spell to restore parity.
Consequently, The Tukkers remain fifth in the Eredivisie table, but have now fallen nine points behind AZ Alkmaar in the race for the final automatic European spot.
Next up is the task of facing off against an opposing outfit with little to choose between the teams as the last six meetings have yielded three wins apiece.
Currently winless in their most recent nine matches on the road, Saturday's visitors will be keen to turn their away fortunes around starting with this weekend's trip to Sittard-Geleen.
Off the back of a tough run of results, Fortuna Sittard showed great resolve to see off the threat of FC Utrecht in a narrow 2-1 triumph at Stadion Galgenwaard on Friday.
Julio Velazquez's men trailed to Anastasios Douvikas's opener just shy of the hour mark but managed to level matters through Kristijan Bistrovic after which Tijjani Noslin completed the turnaround with an 87th-minute strike.
As a result, The Fortunezen have moved up to 11th place in the league standings and are now a whopping 11 points clear of relegation danger, while being just two points adrift of the top half.
Having picked up the third-fewest home points in the entire division, Saturday's hosts will need to get going in front of their fans to build upon what has been a decent campaign to date.
Fortuna Sittard Eredivisie form:
W
D
W
L
L
W
FC Twente Eredivisie form:
D
D
W
L
L
D
FC Twente form (all competitions):
D
L
W
L
L
D
Team News
Wout Brama misses out for Twente due to a long-term ankle problem, while Mathias Kjolo is yet to make his return to action from a broken jawbone.
Michal Sadilek continues to battle with a muscle problem which has seen him sit out the last three games, and the Czech Republic international is a major injury doubt for Saturday.
Twenty-year-old Manfred Ugalde found the back of the net within 120 seconds of coming on as a substitute last time out which could see him rewarded with a place in the starting XI.
Fortuna's Ivo Pinto will be expected to feature right from the off once again after making his return to action from an injury layoff against Utrecht.
Burak Yilmaz has been directly contributed to a goal in each of his last three matches, making the forward one to keep an eye on this weekend.
Fortuna Sittard possible starting lineup:
Pandur; Cox, Siovas, Guth, Pinto; Duarte, Bistrovic; Buitink, Ozyakup, Cordoba; Yilmaz
FC Twente possible starting lineup:
Unnerstall; Sampsted, Hilgers, Propper, Smal; Vlap, Steijn, Bruns; Cerny, Van Wolfswinkel, Cleonise