The hosts are currently on a four-game losing streak, while the visitors have come away empty-handed from each of their last three matches.
Match preview
Karagumruk fell to a narrow 1-0 defeat against Samsunspor when the sides went head-to-head at the Samsun 19 Mayis Stadyumu on Saturday evening.
Shota Arveladze's men looked set to secure a point with the game level heading into its final knockings before Ercan Kara netted an 84th-minute winner.
Consequently, the Black and Red have dropped into the relegation zone as they sit 18th in the Turkish Super Lig table, albeit only one point adrift of safety.
Next up is the challenge of an opposing outfit who boast just one win from the last six editions of this fixture, losing four of the other five.
Having recently seen their five-game unbeaten streak on home turf come to an end, Wednesday's hosts will be keen to avoid consecutive defeats in front of their fans for the first time since May 2023.
Kayserispor were on the receiving end of a disappointing 3-1 defeat against Sivasspor in Sunday's encounter at the Kadir Has Stadyumu.
Recep Ucar's men went behind to Arif Kocaman's own goal but managed to level matters through Stephane Bahoken after which Rey Manaj netted a brace in the second half to decide the contest.
With 29 points from 18 matches so far, the Anatolian Stars sit fourth in the standings, ahead of the chasing pack only on goal difference in the race for the final European spot.
Ahead of a daunting assignment against Galatasaray five days later, Wednesday's visitors now set out in search of a morale-boosting result here.
Fatih Karagumruk Turkish Super Lig form:
L
W
L
L
L
L
Kayserispor Turkish Super Lig form:
D
W
W
L
L
L
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Team News
Karagumruk's Ryan Mendes is currently on international duty with Cape Verde ahead of the upcoming Africa Cup of Nations and will not play any part in this one.
The home side will also be without the services of Stefano Sturaro for a third game on the bounce as he continues to nurse a muscle problem.
Stephane Bahoken made the most of a rare start last time out where he found the back of the net and the forward is expected to retain his place in the XI.
Mame Thiam has been directly involved in 13 of his side's 25 league goals this term, making the 31-year-old one to keep a close watch on.
Fatih Karagumruk possible starting lineup:
Bilgin; Mercan, Dresevic, Ceccherini, Biraschi; Rohden, Paoletti, Eysseric; Yalcin, Keles, Lasagna
Kayserispor possible starting lineup:
Bayazit; Sazdagi, Attamah, Kocaman, Kaldirim; Karimi, Yilmaz, Cardoso; Thiam, Bahoken, Boa Morte