Both sides had to make do with a share of the spoils in their respective last outings and they will be looking to go one better in this weekend's clash.
Match preview
FC Twente played out a goalless stalemate against defending champions Feyenoord when the teams went head to head at De Kuip Stadion on Sunday.
Joseph Oosting's men had their backs against the wall for large spells of the contest but held firm to come away with a hard-fought point.
While The Tukkers have managed just one point from the last six available, they remain third in the Eredivisie table, three points clear of AZ Alkmaar in fourth place.
Coming up next is the challenge of an opposing outfit who have lost just one of the last five editions of this fixture, winning the other four.
However, that solitary loss did come in the most recent encounter back in September when Saturday's hosts fell to a 1-0 defeat in this season's reverse meeting.
Waalwijk snapped a run of back to back defeats with a 1-1 draw against Sparta Rotterdam in Saturday's encounter at the Mandemakers Stadion.
Henk Fraser's men took the lead through Arno Verschueren's own goal eight minutes into the second half before conceding a late equaliser to Joshua Kitolano.
With 15 points amassed from their 19 league matches so far, RKC currently occupy 16th place in the standings, four points adrift of safety.
Having claimed just one win in their last seven matches on the road, Sunday's visitors will need to turn their away fortunes around to stand a good chance of beating the drop.
FC Twente Eredivisie form:
W
W
D
W
L
D
FC Twente form (all competitions):
W
D
W
L
L
D
RKC Waalwijk Eredivisie form:
L
L
D
L
L
D
Team News
Waalwijk's Aaron Meijers received his fifth yellow card of the season against Sparta Rotterdam and will serve a one-game suspension this weekend.
Godfried Roemeratoe was sent off in the aforementioned match, making the midfielder ineligible to feature for the away side in this one.
Max Bruns misses out for FC Twente here as the Dutchman continues his three-game ban for a red card against NEC Nijmegen two Saturdays ago.
Manfred Ugalde has scored each of his side's last three goals and the 21-year-old will be heavily relied upon once again to deliver the goods.
FC Twente possible starting lineup:
Unnerstall; Smal, Propper, Hilgers, Sampsted; Sadilek, Kjolo, Eiting; Vlap, Rots, Brenet
RKC Waalwijk possible starting lineup:
Vaessen; Lelieveld; Van den Buijs, Adewoye, Gaari; Lokesa, Oukili, Cleonise, Felida; Seuntjens, Kramer