With the teams still unbeaten since the turn of the year, they will both be confident of coming away with all three points in what should be a tantalising affair.
Match preview
Feyenoord wasted no time in seeing off the threat of NEC Nijmegen thanks to a routine 2-0 victory in Wednesday's meeting between the sides at De Kuip.
Arne Slot's men raced to an early lead through Javairo Dilrosun's ninth-minute opener after which Orkun Kokcu made the game safe in first-half stoppage time.
As a result, De Stadionclub remain top of the Eredivisie table, two points clear of nearest challengers AZ Alkmaar and a further four clear of PSV Eindhoven in third.
Coming up next is the challenge of an opposing outfit who have proven to be a tough nut to crack, as the last eight meetings have yielded two wins apiece for either team and four stalemates.
Ahead of a crunch clash against PSV seven days later, Sunday's visitors will be aiming to set the tone with a dominant display in this weekend's encounter.
Twente were held to a share of the spoils away from home for the second game running a 2-2 stalemate against Vitesse at the GelreDome on Wednesday.
After edging ahead through Ricky van Wolfswinkel, goals from Gabriel Vidovic and Matus Bero saw Ron Jans's men trail 2-1, before Vaclav Cerny levelled matters just shy of the hour mark.
Picking up eight of the last 12 points available, the Tukkers have climbed up to fourth place in the league table, six points off top spot.
Off the back of nine victories and one draw across their most recent 10 games on home turf, Sunday's hosts now go in search of what would arguably be their most impressive result in front of their fans this term.
FC Twente Eredivisie form:
D
D
W
D
W
D
Feyenoord Eredivisie form:
W
W
D
W
D
W
Feyenoord form (all competitions):
L
W
D
W
D
W
Team News
Twente's Wout Brama continues to nurse an ankle problem which is set to keep the midfielder out of a fourth consecutive match this weekend.
Following his equaliser last time out, Vaclav Cerny has now scored in consecutive matches for the home side for the first time since September, making him one to keep an eye on.
Igor Paixao is a major doubt for this one after the Feyenoord man was subbed off with an injury 10 minutes from half time in the victory over Nijmegen.
Meanwhile, Gernot Trauner is unavailable for the visitors through a damaged knee, while 21-year-old Tein Troost remains down with an arm problem.
FC Twente possible starting lineup:
Unnerstall; Smal, Propper, Hilgers, Sampsted; Kjolo, Zerrouki; Misidjan, Vlap, Cerny; Van Wolfswinkel
Feyenoord possible starting lineup:
Bijlow; Hartman, Hancko, Geertruida, Pedersen; Kokcu, Wieffer; Idrissi, Symanski, Dilrosun; Gimenez