Xabi Alonso's record-breakers made it 33 games unbeaten last weekend, beating Bayern Munich's previous best of 32, and they are big favourites again even if form does go out of the window for a local derby.
Match preview
Leverkusen's title credentials were put to the test last weekend, and they were forced to win ugly against relegation-favourites Mainz, edging past the side second-from-bottom 2-1.
It extended their fairytale unbeaten run which makes it even more likely that the 'Eternal Bridesmaids' may eventually get their moment in the spotlight.
Another feat is within reach this weekend, as they could match a club-record league unbeaten run by going 24 without defeat, as they did in 2009-10; on that occasion, rather peculiarly, their opponents in the 24th game of that run were also Koln.
Only Pep Guardiola's Bayern side have amassed more points at this stage of a Bundesliga campaign than Leverkusen's 61 from 23 games, as Die Werkself are now just 12 points shy of matching their best-ever points total, set back in 1999-00.
With an eight-point gap on Bayern heading into the weekend, no side has ever been caught with such a margin with 11 games to play in the three-point-per-win era, once more stacking the odds in their favour.
Koln have proven difficult opponents in the past though, as they have only completed a league double over their local rivals once in 11 seasons - back in 2020-21.
This is a season like no other though, given Leverkusen's record of 29 wins and four draws from their 33 games in all competitions this season.
A good omen is that Leverkusen beat Koln 3-0 at home that season, as well as 4-0 here at the RheinEnergieStadion, and the reverse fixture earlier this season ended in a 3-0 victory for Alonso's men.
Koln were impressive last weekend in holding third-placed Stuttgart to a 1-1 draw, but they remain rooted in deep trouble along with Mainz and Darmstadt in the bottom three.
The Billy Goats are still in pole position to get a reprieve in the relegation playoff as they currently sit 16th, but they are showing very little signs of catching the sides above them.
An eight-point gap to the four sides level above them looks insurmountable, and no side in the Bundesliga has survived automatically from such a deficit at this stage in over a decade.
Prospects look even more unlikely when it is considered Koln have won just three games all season, and they came against 10-man Borussia Monchengladbach, nine-man Eintracht Frankfurt, and bottom-of-the-table Darmstadt.
FC Koln Bundesliga form:
L
D
W
D
L
D
Bayer Leverkusen Bundesliga form:
W
D
W
W
W
W
Bayer Leverkusen form (all competitions):
D
W
W
W
W
W
Team News
Koln manager Timo Schultz will be able to welcome back Timo Hubers after illness, while Davie Selke could also make a return, but not from the start, after recovering from a broken foot.
Attacking duo Luca Waldschmidt and Mark Uth are absent though, as serious injury has ruled both of them out for the rest of the season.
Leverkusen have been handed a huge boost, as influential midfielder Exequiel Palacios is back in the squad for this one after a brief absence.
The fixture will come too soon for both Victor Boniface and Artur though, as the pair continue to train on their recovery from injury.
FC Koln possible starting lineup:
Schwabe; Carstensen, Chabot, Hubers, Finkgrafe; Huseinbasic, Martel, Kainz; Ljubicic, Thielmann, Maina
Bayer Leverkusen possible starting lineup:
Hradecky; Kossounou, Tah, Hincapie; Frimpong, Andrich, Xhaka, Grimaldo; Adli, Schick, Wirtz
We say: FC Koln 0-3 Bayer Leverkusen
Nothing can stop Leverkusen at the moment, as even when they are off-colour they are still picking up results, as they did against Mainz last time out, and another win is on the cards.