With Leeds United and Leicester City both failing to win last weekend, Everton will begin the day outside the drop zone, as two of the three will be relegated alongside Southampton.
Match preview
After securing Premier League safety last season with one game to spare following a dramatic comeback win over Crystal Palace, Everton will now have their fate sealed on the final day for the first time since 1998.
On that occasion, Everton started the day in the bottom three, but a draw over Coventry City saw them leapfrog Bolton Wanderers who were beaten at Chelsea.
This season though, everything is in their own hands, safe in the knowledge that one more valuable victory will preserve their top-flight status for a 69th-successive campaign.
Leicester's unlikely point at St. James' Park on Monday night makes the task a little more difficult for Everton though, as a draw would have most likely been enough had the Foxes lost in the North East.
There are plenty of potential permutations should Everton slip up given how close the points tallies and goal difference is between the three sides.
A defeat here for the Toffees could still keep them up as long as both Leeds and Leicester do not win, while a draw could also ensure survival as long as Leicester draw or lose and Leeds do not beat Tottenham Hotspur by three or more goals.
Given they went 2-0 down at home to Crystal Palace in their final home game last season, these permutations are likely to come into play at some point during the afternoon, especially considering Everton's surprisingly poor home form in recent weeks.
The last three Premier League matches here at Goodison have all ended in defeat for Sean Dyche's men, conceding 10 goals in the process, as Fulham, Newcastle United and Manchester City all came to Merseyside and recorded convincing victories.
Everton's away form has been much more notable given their reputation as notoriously poor travellers, losing just one of their final seven away matches of the season.
That good record was kept intact by an astonishing finale at Molineux against Wolverhampton Wanderers last Saturday, when after being second-best for the majority of the afternoon, Yerry Mina popped up with a 99th-minute equaliser to heap the pressure on their rivals.
Dominic Calvert-Lewin's first-half injury recurrence represents a huge problem in attack though, as Everton were once again reliant on a central defender finding an all-important goal.
Dwight McNeil is the club's top scorer this season with just seven goals, the lowest tally they have had for their leading marksman since the 2001-02 season.
That illustrates part of the challenge Dyche was presented with when he arrived, but there has been clear improvement given his tally of 18 points from 17 games, compared with Frank Lampard's 15 from 20 matches in the first half of the season.
One worrying statistic is how poor Everton's recent results on the final day have been, as they have drawn one and lost five of their last six encounters on the closing weekend.
Albeit, Everton have had nothing to play for in most of their recent final day outings, but their last three have seen them lose 5-1 at Arsenal, 5-0 at Man City, and, eerily, 3-1 at home to upcoming opponents Bournemouth in 2020.
That result continued a run in which Bournemouth have consistently got the better of Everton, winning in the last four meetings between the sides, scoring 13 times.
The two clubs met twice in a week back in November shortly before the World Cup break, with Bournemouth's second-string side thrashing Everton 4-1 in the EFL Cup, before beating them 3-0 in the league just days later - a pair of results which many Everton fans believed should have resulted in the end of Lampard's tenure at the club.
On their return to the top flight, Bournemouth realistically confirmed their survival weeks ago, after five fantastic wins during April.
The wheels have come off slightly since then, with Gary O'Neil's men losing three in a row as their season draws to a close.
Nevertheless, Bournemouth will join a small group of clubs who have survived despite conceding so many goals.
The 9-0 defeat on their last trip to Merseyside to face Liverpool in August contributes heavily to that, but the Cherries will become just the eighth side in PL history to stay up despite conceding 70+ goals.
They could be joined by Leeds in managing that should Bournemouth do them a favour here, and also Nottingham Forest if they concede three at Palace this weekend.
Everton Premier League form:
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L
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D
Bournemouth Premier League form:
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Team News
Everton's injury worries were compounded in the first half at Molineux last weekend when both Calvert-Lewin and Nathan Patterson were forced off.
The two have been ruled out of this season finale, leaving Dyche with a severe shortage in both positions.
Demarai Gray is expected to be the man to come in to play as a makeshift striker, but the problem at right-back is much more complicated, given that Michael Keane had to briefly fill in there last week as Seamus Coleman is also out.
James Garner took on a right wing-back role in the second half and Alex Iwobi has also played there in the past, so either could start ahead of Mason Holgate who has been out of form, if Dyche opts to go with three centre-backs again.
Conor Coady is back after being ineligible against his parent club last week to offer more options in the centre, but Ben Godfrey is expected to remain sidelined.
One positive is that Vitalii Mykolenko could return after a short absence on the opposite side, meaning McNeil can move further forward after he started at left-back against Wolves.
O'Neil has hinted that he could shake things up with his Bournemouth side for their trip to Merseyside, saying that he is hoping to protect his players ahead of next season now that survival has been secured.
Philip Billing and Hamed Traore both missed their defeat against Manchester United last week and, given O'Neil's comments, could remain out.
Both Marcus Tavernier and Joe Rothwell have been ruled out with thigh injuries, joining Ryan Fredericks and Junior Stanislas on the absentee list.
Everton possible starting lineup:
Pickford; Garner, Keane, Mina, Tarkowski, Mykolenko; Iwobi, Doucoure, Gueye, McNeil; Gray
Bournemouth possible starting lineup:
Neto; Smith, Zabarnyi, Senesi, Vina; Cook, Lerma, Brooks; Christie, Solanke, Outtara
We say: Everton 1-1 Bournemouth
There have been 49 goals scored in the 13 head-to-head clashes between these two sides, but with what is on the line, this should be a very different kind of game.