The visitors, on the other hand, make the journey to Hampshire looking to preserve their current 13-game unbeaten run across all competitions.
Match preview
Eastleigh snapped a run of three straight defeats courtesy of a hard-fought 1-0 triumph over Boreham Wood in Saturday's meeting between the teams.
Lee Bradbury's men opened the scoring 11 minutes shy of the interval through Tristan Abrahams and that was enough to secure all three points.
As a result, The Spitfires sit ninth in the National League table, two points behind the last playoff spot albeit having played a game more.
Up next is the challenge of an opposing outfit who have only suffered one defeat in the previous 18 editions of this fixture dating back to 2014.
However, Saturday's hosts are unbeaten in all but one of their last 13 matches on home turf heading into this weekend's contest in front of what is sure to be an expectant home support.
Wrexham had to settle for a share of the spoils when they took on York City in a 1-1 stalemate at the LNER Community Stadium on Saturday.
Phil Parkinson's men broke the deadlock in the 88th minute through Thomas O'Connor and were on course to come away with all three points before Immanuelson Duku levelled matters in second-half stoppage time.
Having picked up 47 points from 21 games so far, The Red Dragons are second in the league standings, one point behind Notts County at the top of the pile.
Currently with the second fewest goals conceded away from home in the entire division, Saturday's visitors will be confident of keeping their opponents at bay this weekend.
Eastleigh National League form:
W
W
L
L
L
W
Eastleigh form (all competitions):
L
W
L
L
L
W
Wrexham National League form:
W
W
W
D
W
D
Wrexham form (all competitions):
W
W
D
W
W
D
Team News
Nigel Atangana was hauled off in the first half of Eastleigh's victory over Boreham Wood last time out, making the midfielder a doubt for this one.
With two goals in his last three home appearances for the hosts, Tristan Abrahams will be looking to come up with the goods for his side once again.
Thomas O'Connor came off the bench to good effect for Wrexham last time out and the Ireland international could be rewarded with a place in the starting XI.
Off the back of a two-goal haul in the last clash between Saturday's opponents back in August, 27-year-old Elliott Lee is one to look out for.
Eastleigh possible starting lineup:
McDonnell; Rutherford, Maghoma, Langston, Kelly; Lloyd, Cisse, Carter; Abrahams, Whitehall, Hill
Wrexham possible starting lineup:
Howard; McFadzean, Tunnicliffe, Tozer, Hayden, Forde; Lee, Young, Jones; Mullin, Palmer